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1. Histamine catabolism in vivo was studied in mice and rats; tissues from animals killed 2.5 min after intravenous injection of (14)C-histamine were assayed for (14)C-histamine and total (14)C. Aminoguanidine, a diamine oxidase inhibitor, and methylhistamine, an inhibitor of the histamine methylating enzyme, were used to evaluate the roles of these enzymes(More)
The antihistaminic activity of many antidepressant drugs is well documented in vitro but has not been investigated as thoroughly in vivo. In the course of an investigation of the roles of H1 and H2 receptors in histamine-induced adrenocorticotropic hormone (ACTH) release in rats, it was observed that several antidepressants were potent inhibitors of this(More)
1. Histamine catabolism in vivo was studied in mice subjected to various forms of pretreatment; tissues from mice killed 2.5 min after intravenous injection of (14)C-histamine were assayed for (14)C-histamine, (14)C-methylhistamine and total (14)C.2. Pretreatment of mice with aminoguanidine, an inhibitor of diamine oxidase, strongly increased levels of(More)
1. Mice were injected with ((14)C)-L-histidine, killed at various intervals, and tissues assayed for ((14)C)-histamine. In some cases free ((14)C)-L-histidine and total ((14)C) were also determined.2. Removal of stomach, the most active histamine-forming tissue, failed to reduce the ((14)C)-histamine content of any tested tissue; ((14)C)-histamine(More)