Michael A. Penman

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Fatigue occurs in a majority of patients with MS and is generally independent of measurable neurologic disability. Few options for treatment are available. We conducted a double-blind, placebo-controlled, crossover trial for each of two 4-week treatment periods. Forty-six eligible patients entered and five dropped out due to concurrent exacerbations.(More)
We treated 13 patients with progressive MS with mitoxantrone. All patients received a standard IV dose of mitoxantrone (8 mg/m2) every 3 weeks for a total of seven infusions, with dosage adjustments depending on the hematologic profile at the nadir. The treatment was well tolerated, with the most common side effect being mild nausea. Four of seven women(More)
'We, on the whole, do our Hero-worship worse than any other Nation in this world ever did it before.' Introduction In a recent survey of public opinion in Scotland, the figure of Robert Bruce, king of Scots (1306-29), was ranked third, with 12% of the vote, in a list of 'most important Scots.' Bruce thus posted, arguably quite predictably, behind, first,(More)
The initial concerns of this Reputations study were twofold. Firstly, that it would find that Robert Bruce only existed in the shadow of his predecessor in Scotland's medieval fight against England, the purer patriot William Wallace (d. 1305). Secondly, in working its way through works of the late eighteenth-and early nineteenth-centuries, that it would(More)
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