Michael A Marentette

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OBJECTIVES To identify determinants of cyclooxygenase 2 (COX-2) inhibitor versus nonsteroidal antiinflammatory drug (NSAIDs) or acetaminophen prescription in seniors; and to compare gastroprotective agent coprescriptions. METHODS Administrative medical records were obtained from the government of Quebec health insurance agency. Three cohorts were formed(More)
BACKGROUND Clinical trials have shown rofecoxib, a selective inhibitor of cyclo-oxygenase-2, to be associated with fewer gastrointestinal complications than non-selective nonsteroidal anti-inflammatory drugs (NSAIDs). OBJECTIVE To evaluate the potential clinical and economic consequences of rofecoxib prescription in Ontario, Canada, for patients with(More)
The objective was to assess persistence with antihypertensive therapy (AHT) and discontinuation patterns in patients newly dispensed different antihypertensive drug classes in a natural Canadian population-based setting. Hypertensive patients initiating AHT monotherapy were included in this 3-year retrospective cohort study (N=21 326) using the Saskatchewan(More)
OBJECTIVE To assess the appropriateness of nonsteroidal anti-inflammatory drug (NSAID) use relative to recent osteoarthritis treatment guidelines from the Second Canadian Consensus Conference. STUDY DESIGN Observational study of self-reported practice in a cohort of physicians from the Canadian Osteoarthritis Rx (CANOAR) study. SUBJECTS AND METHODS(More)
BACKGROUND The Reduction of Endpoints in NIDDM [non-insulin-dependent diabetes mellitus] with the Angiotensin II Antagonist Losartan (RENAAL) study demonstrated the renoprotective effects of losartan in patients with nephropathy from type 2 diabetes. OBJECTIVE To perform an economic evaluation of the costs associated with end-stage renal disease (ESRD)(More)
BACKGROUND Noncompliance with antihypertensive therapy is a major problem that hinders successful hypertension management. OBJECTIVE To study antihypertensive drug persistence for hypertensive patients in routine clinical settings. METHODS Hypertensive patients were retrospectively studied (1994 through 1998) using databases managed by Saskatchewan(More)
INTRODUCTION This analysis compared the cost effectiveness of adding ezetimibe to atorvastatin therapy versus atorvastatin titration or adding cholestyramine (a resin) for patients at high risk of a coronary artery disease (CAD) event who did not reach target cholesterol levels on their current atorvastatin dosage. The primary analysis focused on(More)
BACKGROUND Although statins are widely used to reduce low density lipoprotein cholesterol (LDL-C), there is little information about patient profiles, treatment patterns and goal achievement among statin-treated patients in Canada. OBJECTIVES To assess the profile of statin-treated patients and to determine whether they are achieving recommended targets(More)
BACKGROUND Migraine is prevalent and associated with substantial direct and indirect costs that may vary across geographic and national boundaries. The effects of migraine, self-reported by Canadians, on health care resource use as well as paid and unpaid work loss were examined. PATIENTS AND METHODS The Migraine Background Questionnaire (MBQ) was(More)
OBJECTIVE Several randomized controlled trials indicate that a low density lipoprotein cholesterol (LDL-C) target <2.0 mmol/L is appropriate for individuals at high risk of coronary artery disease (CAD). Recently released Canadian lipid management guidelines (2006) have incorporated this evidence into their recommendations. A cross-sectional study of(More)