Michael A Jeannot

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A hanging microliter drop of 1-octanol is shown to be an excellent preconcentration medium for headspace analysis of volatile compounds in an aqueous matrix by gas chromatography (GC) or gas chromatography/mass spectrometry (GC/MS). Model compounds benzene, toluene, ethylbenzene, and o-xylene (BTEX) are conveniently and rapidly preconcentrated in the(More)
An analytical technique is described which combines solvent extraction with gas chromatographic (GC) analysis in a simple and inexpensive apparatus involving very little solvent consumption. A small drop (8 μL) of a water-immiscible organic solvent, containing an internal standard, is located at the end of a Teflon rod which is immersed in a stirred aqueous(More)
Matrix-assisted laser desorption ionization (MALDI) time-of-flight mass spectrometry (TOFMS) can potentially provide accurate molecular weight information of proteins separated by sodium dodecylsulfate polyacrylamide gel electrophoresis (SDS-PAGE). Several issues related to resolution and accuracy of molecular weight measurement are investigated by using a(More)
Single drop microextraction (SDME) has emerged over the last 10-15 years as one of the simplest and most easily implemented forms of micro-scale sample cleanup and preconcentration. In the most common arrangement, an ordinary chromatography syringe is used to suspend microliter quantities of extracting solvent either directly immersed in the sample, or in(More)
A 1-microL drop of n-octane suspended from the tip of a microsyringe needle in 500 mL of stirred aqueous solution is used to extract unbound progesterone in the presence of 1% (w/v) bovine serum albumin (BSA) for analysis by gas chromatography (GC). The observed extraction kinetics are in good agreement with a proposed convective-diffusive mass transfer(More)
A general kinetic model for headspace solvent microextraction (HS-SME) is described which incorporates steady-state behavior of the concentration of the analyte in the headspace phase during the extraction process. The model is consistent with previously reported extraction rate data, and provides a fundamental framework for understanding the(More)
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