Michael A. Henderson

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Differences in gene expression are likely to explain the phenotypic variation between hormone-responsive and hormone-unresponsive breast cancers. In this study, DNA microarray analysis of approximately 10,000 known genes and 25,000 expressed sequence tag clusters was performed to identify genes induced by estrogen and repressed by the pure antiestrogen ICI(More)
In a prospective study of 526 consecutive patients with operable breast cancer, the significance of positive parathyroid hormone-related protein (PTHrP) staining by immunohistology has been evaluated for a median of 10-year follow-up. Improved survival was observed for the 79% of tumors which stained positively for PTHrP [estimated univariate hazard ratio,(More)
Mammographic density (MD), after adjustment for a women’s age and body mass index, is a strong and independent risk factor for breast cancer (BC). Although the BC risk attributable to increased MD is significant in healthy women, the biological basis of high mammographic density (HMD) causation and how it raises BC risk remain elusive. We assessed the(More)
INTRODUCTION The ability to screen blood of early stage operable breast cancer patients for circulating tumour cells is of potential importance for identifying patients at risk of developing distant relapse. We present the results of a study of the efficacy of the immunobead RT-PCR method in identifying patients with circulating tumour cells. RESULTS(More)
The Advanced Tokamak scenario, one of the modes of operation being considered for ITER, relies on the attainment of a high bootstrap current fraction. This scenario is typically characterized by an internal transport barrier (ITB). An internal feedback loop then governs the current profile, which strongly affects the confinement and thus the properties and(More)
Confinement in TCV electron cyclotron heated discharges was studied as a function of plasma shape, i.e. as a function of elongation, 1.1 < κ < 2.15, and triangularity, −0.65 ≤ δ ≤ 0.55. The electron energy confinement time was found to increase with elongation, owing in part to the increase of plasma current with elongation. The beneficial effect of(More)
An interpretation of non-standard, central MHD events in the TCV tokamak during localized ECRH is presented. It is shown that the non-standard behaviour is a consequence of specific features in the electron temperature profile produced when ECRH power is deposited close to the q = 1 surface and by the advection and mixing of electron thermal energy(More)
Different types of central relaxation oscillations are observed in the presence of ECH depending on the location of the deposited power. In the TCV tokamak, normal sawteeth, i.e. triangular sawteeth similar to ohmic sawteeth, and saturated sawteeth are observed with central ECH power deposition, while giant sawteeth and 'humpback' oscillations occur when(More)
High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is associated with BCs of more advanced stages. However, it is unclear whether BC progression and metastasis are stimulated by HMD. We investigated whether patient-derived HMD breast tissue could stimulate the progression of MCF10DCIS.com cells(More)
The dynamics of chemisorbed species as they swing to-and-fro on their adsorption sites may be directly observed with electron-stimulated desorption. The observation of the thermal disorder in adsorbate chemical bond directions, through studies of the thermal excitation of librational modes, allows one to visualize the potential energy surfaces controlling(More)
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