Michael A. Goldman

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DNA replication in mammals is temporally bimodal. "Housekeeping" genes, which are active in all cells, replicate during the first half of the S phase of cell growth. Tissue-specific genes replicate early in those cells in which they are potentially expressed, and they usually replicate late in tissues in which they are not expressed. Replication during the(More)
Mammalian X-chromosome inactivation involves a coordinate shutting down of physically linked genes. Several proposed models require the presence of specific sequences near genes to permit the spread of inactivation into these regions. If such models are correct, one might predict that heterologous genes transferred onto the X chromosome might lack the(More)
The American Society for Cell Biology takes public policy issues very seriously. At the Society's 42nd annual meeting, one key concern was research funding. Elias Zerhouni, the new Director of the US National Institutes of Health (NIH; Bethesda, USA) addressed issues of funding, the direction of science and the way in which it must be practised in the(More)
Aims: Recent genetic studies have linked serotonin-related genetic polymorphisms with diverse disorders characterized by functional somatic symptoms, including chronic fatigue syndrome, irritable bowel syndrome, and premenstrual dysphoric disorder. Methods: We investigated three serotonin-related genetic polymorphisms by screening genomic DNA of 36(More)
We have come so far so fast in understanding RNA interference (RNAi) and its central role in biology. Rarely has a novel mechanism in molecular genetics had such broad implications, ranging from gene therapy and drug discovery to our very understanding of what the word 'gene' means. Every major pharmaceutical company has a substantial effort now in RNAi(More)
one of my mentors said " You're leaving the priesthood. " Not many people put it that baldly, but indeed the two most obvious drawbacks young scientists see in my choice are a loss of prestige, and the assumption that competitive research must be abandoned. Research has indeed been more of a struggle since I moved to SFSU. But recently I've seen a rapid(More)
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