Michael A. Fisher

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The Oak Ridge fault is a large-offset, south-dipping reverse fault that forms the south boundary of the Ventura Basin in southern California. Previous research indicates that the Oak Ridge fault south of the town of Ventura has been inactive since 200–400 ka ago and that the fault tip is buried by ϳ 1 km of Quaternary sediment. However, very high-resolution(More)
We studied the role of P-selectin, an adhesion molecule known to be important for neutrophil localization to sites of inflammation, in a model of inflammatory liver injury. Male C3Heb/FeJ (ET-sensitive) mice treated with 700 mg/kg galactosamine and 100 microg/kg Salmonella abortus equi endotoxin (Gal/ET), murine tumor necrosis factor alpha (TNF-alpha, 15(More)
A central challenge of synthetic biology is to enable the growth of living systems using parts that are not derived from nature, but designed and synthesized in the laboratory. As an initial step toward achieving this goal, we probed the ability of a collection of >10(6) de novo designed proteins to provide biological functions necessary to sustain cell(More)
We interpret seismic-reflection data, which were collected in Santa Monica Bay using a 70-in 3 generator-injector air gun, to show the geologic structure of the continental shelf and slope and of the deep-water, Santa Monica and San Pedro Basins. The goal of this research is to investigate the earthquake hazard posed to urban areas by offshore faults. These(More)
1999 This report is preliminary and has not been reviewed for conformity with U.S. Geological Survey editorial standards or with the North American Stratigraphic Code. Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government INTRODUCTION Project objectives The focus of the Southern(More)
On April 1, 2007, a destructive earthquake (Mw 8.1) and tsunami struck the central Solomon Islands arc in the southwestern Pacific Ocean. The earthquake had a thrust-fault focal mechanism and occurred at shallow depth (between 15 km and 25 km) beneath the island arc. The combined effects of the earthquake and tsunami caused dozens of fatalities and(More)
The Seattle fault, a large, seismically active, east–west-striking fault zone under Seattle, is the best-studied fault within the tectonically active Puget Low-land in western Washington, yet its subsurface geometry and evolution are not well constrained. We combine several analysis and modeling approaches to study the fault geometry and evolution,(More)
Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Although this report is in the public domain, permission must be secured from the individual copyright owners to reproduce any copyrighted material contained within this report. Executive Summary This report examines the geologic(More)
High-resolution seismic-reflection data are combined with a variety of other geophysical and geological data to interpret the offshore structure and earthquake hazards of the San Pedro shelf, near Los Angeles, California. Prominent structures investigated include the Wilmington graben, the Palos Verdes fault zone, various faults below the west part of the(More)
The present study was designed to determine the effects of denervation on glycoprotein synthesis in the predentinal matrix of the mouse incisor. The inferior alveolar nerve (IAN), superior cervical gan-glion (SCG) or both (IAN+ SCG) were unilaterally resected in adult mice with the contralateral side remaining intact as a control. Fourteen days after(More)