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The number of N-glycans (n) is a distinct feature of each glycoprotein sequence and cooperates with the physical properties of the Golgi N-glycan-branching pathway to regulate surface glycoprotein levels. The Golgi pathway is ultrasensitive to hexosamine flux for the production of tri- and tetra-antennary N-glycans, which bind to galectins and form a(More)
| Detection of incipient (slowly developing) faults is crucial in automated maintenance problems where early detection of worn equipment is required. In this note, a general framework for model-based fault detection and diagnosis of a class of incipient faults is developed. The changes in the system dynamics due to the fault are modeled as nonlinear(More)
Genetic information flows from DNA to macromolecular structures-the dominant force in the molecular organization of life. However, recent work suggests that metabolite availability to the hexosamine and Golgi N-glycosylation pathways exerts control over the assembly of macromolecular complexes on the cell surface and, in this capacity, acts upstream of(More)
A model reference adaptive control law is deened for nonlinear distributed parameter systems. The reference model is assumed to be governed by a strongly coercive linear operator deened with respect to a Gelfand triple of reeexive Banach and Hilbert spaces. The resulting nonlinear closed loop system is shown to be well posed. The tracking error is shown to(More)
The problem of estimating a spatially distributed process described by a partial differential equation (PDE), whose observations are contaminated by a zero mean Gaussian noise, is considered in this work. The basic premise of this work is that a set of mobile sensors achieve better estimation performance than a set of immobile sensors. To enhance the(More)
An undesirable release of a gaseous substance in the atmosphere can pose a significant threat. To minimize the negative impact of this release, it is important to predict the state of the release as well as the proximity of the source location. This work investigates the real time detection and state estimation of an aerial release due to a stationary or(More)
Multiple sclerosis (MS) is characterized by inflammatory demyelination of axons and neurodegeneration, the latter inadequately modeled in experimental autoimmune encephalomyelitis (EAE). Susceptibility of inbred mouse strains to EAE is in part determined by major histocompatibility complex haplotype; however, other molecular mechanisms remain elusive.(More)
The differentiation of naive CD4(+) T cells into either proinflammatory Th1 or proallergic Th2 cells strongly influences autoimmunity, allergy, and tumor immune surveillance. We previously demonstrated that beta1,6GlcNAc-branched complex-type (N-acetylglucosaminyltransferase V (Mgat5)) N-glycans on TCR are bound to galectins, an interaction that reduces TCR(More)