Michael A. Ceddia

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Vitamin A deficiency diminishes Th2-mediated Ab responses, and high-level dietary vitamin A or treatment with the vitamin A metabolite retinoic acid (RA) enhances such responses. To identify a potential mechanism(s) underlying this in vivo activity of vitamin A, we examined the effects of all-trans and 9-cis RA on development of Th1 and Th2 cell populations(More)
The evaluation of anti-aging intervention strategies in dogs would benefit from reliable quantitative biomarkers of aging. In the present study, the expression of various immune parameters was measured in young and old dogs to identify potential biomarkers of aging. The second goal of the study was to determine the effect of age on the immune response to(More)
A proprietary dry spearmint extract containing 15.4% rosmarinic acid was assessed in a 90-day study with Sprague-Dawley rats that were gavaged at 0, 422 (low), 844 (mid), or 1948 (high) mg dry spearmint extract/kg bw/day, (equivalent to 0, 65, 130, or 300 mg rosmarinic acid/kg bw/day, respectively). No treatment-related clinical signs or adverse effects(More)
Oxidative damage is one of the hallmarks of the aging process. The current study evaluated effects of two proprietary antioxidant-based ingredients, rosemary extract and spearmint extract containing carnosic acid and rosmarinic acid, respectively, on learning and memory in the SAMP8 mouse model of accelerated aging. The two rosemary extracts contained(More)
Mounting research demonstrates that certain nutraceutical compounds interact with the immune system. These interactions may be positive or negative depending on the compound or dose administered to the individual. Understanding the mechanisms by which these compounds work should provide opportunities to design nutritional interventions to bolster the health(More)
BACKGROUND Exercise can initiate a cascade of inflammatory and oxidative stress-related events leading to delayed onset muscle soreness. Polyphenols possess antioxidant and anti-inflammatory properties. OBJECTIVE The current study examined the effects of a proprietary polyphenolic blend (PB), containing catechins and theaflavins, on exercise performance(More)
OBJECTIVES The objective of this study was to examine the effects of a green and black tea extract blend [AssuriTEA Men's Health (AMH)] in men with lower urinary tract symptoms (LUTS). METHODS In this randomized, double-blind, placebo-controlled study, 46 men aged 30-70 with an American Urologic Association symptom score (AUAss) of at least 8 and up to 24(More)
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