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RATIONALE Heterogeneity in asthma expression is multidimensional, including variability in clinical, physiologic, and pathologic parameters. Classification requires consideration of these disparate domains in a unified model. OBJECTIVES To explore the application of a multivariate mathematical technique, k-means cluster analysis, for identifying distinct(More)
OBJECTIVE Current scoring systems, which adjust prediction for severity of illness, do not account for higher observed mortality in neonatal intensive care units (NICUs) of children's hospitals than that of perinatal centers. We hypothesized that three potential predictors, (a) admission from another NICU, (b) presence of congenital anomalies and (c) need(More)
BACKGROUND There is debate about the mechanisms of persistent airflow limitation in patients with asthma. Chronic inflammation is assumed to be important, although there is limited and contradictory information about the relationship between airway inflammation and postbronchodilator FEV1. METHODS We have assessed the cross-sectional relationship between(More)
The study examines the relationship between several measures of fitness and the lipid profile in United States astronauts. Data were collected on 89 astronauts, previously selected (PSA) and newly selected (NSA), during their annual physical examinations. Several similarities were seen in the two groups. The PSA (mean age of 46.1) had a lower maximum VO2(More)
OBJECTIVE To describe growth during initial hospitalization for very small premature infants fed intravenous hyperalimentation, then calcium supplemented 1460 mg/L (36.5 mmol/L) 81 kcal preterm formula. POPULATION A total of 109 survivors whose <1000 g birth weight was appropriate for gestational age. Mean gestational age was 25.8 weeks. RESULTS Graphs(More)
OBJECTIVE To quantify the factors associated with growth of very small premature infants during initial hospitalization. POPULATION Study patients were 109 infants who were appropriate for gestational age, weighed <1000 g at birth, and were fed intravenous hyperalimentation then calcium-supplemented 81-kcal preterm formula according to a protocol. (More)
Hypertension is a significant illness that affects a large portion of the population of the United States. We have determined the extent of this illness within the civilian pilot population of the U.S. We reviewed data pertaining to the current prevalence of hypertension in the general population and compared these results to similar data on the pilot(More)
BACKGROUND AND OBJECTIVE We have suggested that chronic inflammation of other foregut derivatives might be associated with airway inflammation and amplification of the response to inhaled stimuli such as cigarette smoke leading to chronic obstructive pulmonary disease (COPD). One of the commonest causes of chronic foregut inflammation is gastritis secondary(More)