Michael A. Altmann

Learn More
RNA helicases represent a large family of proteins implicated in many biological processes including ribosome biogenesis, splicing, translation and mRNA degradation. However, these proteins have little substrate specificity, making inhibition of selected helicases a challenging problem. The prototypical DEAD box RNA helicase, eIF4A, works in conjunction(More)
The Drosophila genome-sequencing project has revealed a total of seven genes encoding eight eukaryotic initiation factor 4E (eIF4E) isoforms. Four of them (eIF4E-1,2, eIF4E-3, eIF4E-4 and eIF4E-5) share exon/intron structure in their carboxy-terminal part and form a cluster in the genome. All eIF4E isoforms bind to the cap (m7GpppN) structure. All of them,(More)
The 5' cap structure of trypanosomatid mRNAs, denoted cap 4, is a complex structure that contains unusual modifications on the first four nucleotides. We examined the four eukaryotic initiation factor 4E (eIF4E) homologues found in the Leishmania genome database. These proteins, denoted LeishIF4E-1 to LeishIF4E-4, are located in the cytoplasm. They show(More)
JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. are collaborating(More)
With the successful completion of Gallex after more than six years of operation and the smooth transition to Gno a milestone in radiochemical solar neutrino recording has been reached. The Gallex solar neutrino result, 76 8 SNU, being signiicantly below all solar model predictions, connrms the long standing solar neutrino puzzle and constitutes an(More)
An improvement of both, the statistical and systematic uncertainty beyond the level achieved in Gallex is an essential prequisite for Gno. As major contributions to these errors are associated with the detection of the EC-decay of 71 Ge in miniaturized gas proportional counters, low temperature calorimetric detectors might provide an appealing alternative(More)
An improvement of both, the statistical and systematic uncertainty beyond the level achieved in GALLEX is an essential precondition for GNO to successfully meet its scientiic goals. At present, major contributions to these errors are associated with the detection of the EC-decay of 71 Ge in miniaturized low-background proportional counters. We have started(More)
eIF4E, the cytoplasmatic cap-binding protein, is required for efficient cap-dependent translation. We have studied the influence of mutations that alter the activity and/or expression level of eIF4E on haploid and diploid cells in the yeast S. cerevisiae. Temperature-sensitive eIF4E mutants with reduced levels of expression and reduced cap-binding affinity(More)
Ethanolamine phosphoglycerol (EPG) is a protein modification attached exclusively to eukaryotic elongation factor 1A (eEF1A). In mammals and plants, EPG is linked to conserved glutamate residues located in eEF1A domains II and III, whereas in the unicellular eukaryote Trypanosoma brucei, only domain III is modified by a single EPG. A biosynthetic precursor(More)