Michael A. Allen

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OBJECTIVE To investigate whether antidrug antibodies and/or drug non-trough levels predict the long-term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors influencing antidrug antibody and drug levels to optimize future treatment decisions. METHODS A total of 331(More)
The rate constant for the hydrolysis of prostacyclin (PGI2) to 6-keto-PGF1alpha was measured by monitoring the UV spectral change, over a pH range 6 to 10 at 25 degrees C and the total ionic strength of 0.5 M. The first-order rate constant (kdegreesobs) extrapolated to zero buffer concentration follows an expression, kdegreesobs = kH+ (H+), where kH+ is a(More)
BACKGROUND Atopic dermatitis (AD) is a major inflammatory condition of the skin caused by inherited skin barrier deficiency, with mutations in the filaggrin gene predisposing to development of AD. Support for barrier deficiency initiating AD came from flaky tail mice, which have a frameshift mutation in Flg and also carry an unknown gene, matted, causing a(More)
The SLAC electron-positron colliding-beam project SPEAR was completed and stable colliding beams were achieved in April, 1972, after a construction period of approximately 20 months. Since that time, an active experimental high-energy physics program has begun in addition to a program of continued studies of accelerator physics. This paper discusses only(More)
Specific labelling of target cell surfaces using antibody-conjugated paramagnetic nanobeads is essential for efficient magnetic cell separation. However, studies examining parameters determining the kinetics of bead-cell binding are scarce. The present study determines the binding rates for specific and unspecific binding of 150 nm paramagnetic nanobeads to(More)
The next generation of linear colliders requires peak power sourcesof-over 200 MW per meter at frequencies above 10 GHz at pulse widths of less than 100 nsec. Several power sources are under active development, including a conventional klystron with RF pulse compression, a relativistic klystron (RK) and a crossed-field amplifier. Power from one of these has(More)
The next linear collider will require 200 MW of RF power per meter of linac structure at relatively high frequency to produce an acc.elerating gradient of about 100 MV/m. The higher frequencies result in a higher breakdown threshold in the accelerating structure hence permit. higher a.ccelerating gradients per meter of linac. The lower frequencies have the(More)