Micha Milovanovic

Learn More
Stroke is worldwide a leading cause of death and disability. Its etiology is regarded as heterogeneous. Platelets are implicated in its pathophysiology, but our understanding of their specific role is incomplete. Only sparse and conflicting information exists about platelet reactivity and activity in acute stroke. Some scientists take the view that(More)
AIM OF THE STUDY To investigate platelets and different inflammatory markers in conjunction with a substantial inflammatory reaction. We used individuals with active rheumatoid arthritis (RA) as an experimental cohort. METHODS We selected 16 patients with active RA having at least one affected joint. On day 1, platelet and neutrophil counts together with(More)
OBJECTIVE Knowledge concerning the neurobiological importance of platelets in Alzheimer's disease (AD) is sparse. P-selectin, which is located together with β-amyloid precursor proteins in platelet α-granules, is also found in endothelial cells. Upon activation, P-selectin is relocated to cell surfaces where it acts as a receptor. Subsequently, the protein(More)
The present study examines biochemical and functional characteristics of platelet density subpopulations together with their ability to mobilise intracellular fibrinogen when activated. Platelets from three healthy volunteers were investigated. The total platelet population was separated according to density in a linear Percoll gradient in a plasma-free(More)
Platelets contain a substantial quantity of amyloid-precursor protein (APP) and β-amyloid. However, despite the large importance of APP and β-amyloid to dementia, little is known about platelets in sporadic Alzheimer dementia (AD). Furthermore, platelet heterogeneity influences human pathology and has been described to affect the progression of AD. This(More)
Age (years) 63±8(SD) 60±8(SD) NS Male/ female (n) 36/15 79/19 NS No. of diseased coronary arteries 2.1±0.9(SD) 1.8±0.8(SD) p<0.05 Previous MI, (n, %) 17 (33) 32 (33) NS Previous hypertension, (n, %) 25 (49) 38 (39) NS Smoking, (n, %) 5 (10) 15 (15) NS Medication at admission Aspirin (n, %) 44 (86) 93 (95) NS β-blockers (n, %) 42 (82) 89 (91) NS(More)
This work investigates relationships between platelet density and reactivity. 21 individuals subject to coronary angiography were studied. Peak platelet density was analyzed using a newly developed electronic device. The apparatus measures light transmission through test tubes containing density-separated platelets, thus allowing an estimation of the(More)
INTRODUCTION Alzheimer's disease (AD) is a progressive form of dementia characterized by an increase in the toxic substance β-amyloid in the brain. Platelets display a substantial heterogeneity with respect to density. They further contain a substantial amount of β-amyloid precursor protein. Platelets take up and store serotonin (5-HT) that plays an(More)
BACKGROUND The current study investigates circulating eosinophils and neutrophils in Alzheimer's (AD) type dementia with respect to density (kg/L). The existence of β-amyloid plaques in the brain is a feature of AD. Sporadic scientific reports indicate that the disease affects circulating neutrophils. In contrast, numerous publications investigate(More)
BACKGROUND The impact of atrial fibrillation (AF) upon platelet reactivity has not been investigated. METHODS Subjects were 33 individuals with AF who consented to elective electrical cardioversion (ECV) immediately before ECV determination of surface-bound fibrinogen after stimulation i.e. platelet reactivity was carried out. A flow cytometer was(More)