Michał Woźniak

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BACKGROUND Inhibition of the renin-angiotensin-aldosterone system (RAAS) with angiotensin converting enzyme inhibitors (ACEI) and/or angiotensin II subtype 1 receptor antagonists (ARB) is a common strategy used in the management of patients with chronic kidney disease (CKD). However, there is no universal therapy that can stop progression of CKD.(More)
We have demonstrated for the first time that the steroid metabolite, 2-methoxyestradiol (2-ME) is a powerful growth inhibitor of human osteosarcoma 143 B cell line by pleiotropic mechanisms involving cell cycle arrest at two different points and apoptosis. The ability of 2-ME to inhibit cell cycle at the respective points has been found concentration(More)
Serine proteases HtrA1 and HtrA2 are involved in cellular stress response and development of several diseases, including cancer. Our aim was to examine the involvement of the HtrA proteins in acute oxidative stress response induced in hamster kidney by estrogen treatment, and in nephrocarcinogenesis caused by prolonged estrogenization of male Syrian(More)
The purpose of this study was to examine the application of the coordinated cis-[Cr(C2O4)(pm)(OH)2]+ cation where pm denotes pyridoxamine, as a specific sensing ion for the detection of hydrogen peroxide (H2O2). The proposed method for H2O2 detection includes two key steps. The first step is based on the nonenzymatic decarboxylation of pyruvate upon(More)
Contemporary medicine should provide high quality diagnostic services while at the same time remaining as comfortable as possible for a patient. Therefore novel non-invasive disease recognition methods are becoming one of the key issues in the health services domain. Analysis of data from such examinations opens an interdisciplinary bridge between the(More)
Characterization of free radical-induced cell injury processes of placenta cells is of vital importance for clinical medicine for the maintenance of intrauterine fetal life. The present study has analyzed cell injury processes in cells of the choriocarcinoma cell line JAR treated with menadione, an anticancer drug, and H(2)O(2) in comparison to osteosarcoma(More)
Paper deals with the knowledge acquisition process. Different experts formulate the rules for decision support systems. We assume they have different knowledge about the problem and therefore obtained rules have different qualities. We will formulate the proposition of the confidence measure and its application to the decision process. We will propose how(More)
Computational aspects of the presence of drug resistance mechanisms PhD dissertation Thesis supervisor prof. dr hab. Acknowledgements First, I want to thank my advisor Jerzy Tiuryn and my co-advisor Limsoon Wong for working with me on this project. They gave me guidance and freedom, setting a great example of how to approach research problems. The(More)
The effects of inhibitors of plasma membrane NADPH oxidase on menadione-induced cell injury processes were studied using human osteosarcoma 143B cells. The intracellular level of superoxide in the cells treated with menadione for 6 h reached a maximum followed by an abrupt decrease. The population of apoptotic cells detected by Annexin V and propidium(More)