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Variants in the CHEK2 have been found to be associated with prostate cancer risk in the United States and Finland. We sequenced CHEK2 gene in 140 Polish patients with prostate cancer and then genotyped the three detected variants in a larger series of prostate cancer cases and controls. CHEK2 truncating mutations (IVS2 + 1G>A or 1100delC) were identified in(More)
Purpose To estimate and to compare ten-year survival rates in unselected patients with early-onset breast cancer, with and without a BRCA1 mutation. To identify prognostic factors among unselected BRCA1-positive breast cancer patients. 3354 women who were diagnosed with stage I to stage IV breast cancer, at or below 50 years of age, between January 1996 and(More)
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