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The electrophysiological properties of a cardiac cell line (MCM1) originating from a transgenic mouse were characterized. The dominant current in these cells is a sodium current that is insensitive to concentrations of tetrodotoxin (TTX) up to 100 microM. It activates and inactivates rapidly with half-maximal activation at -40 mV and half-maximal(More)
In an attempt to determine whether dehydration (intravascular fluid depletion) alters the radiologic or histologic picture of segmental Streptococcus pneumoniae pneumonia, we induced pneumonia in 2 groups of dogs, group 1 (normally hydrated) and group 2 (dehydrated). Five hours after the intrabronchial instillation of a brain-heart-Streptococcus pneumoniae(More)
Cardiac output, renal and hepatic blood flows, arterial lactate concentration, and minute volume were measured before, during, and after 40 min of rest induced either by the practice known as "transcendental meditation" (TM) or by an ordinary eyes-closed rest-relaxation period. Two groups of normal young adults were studied: one group consisted of regular(More)
Earlier studies demonstrated that deprivation of growth hormone (GH) for >/=3 h decreased basal and maximally stimulated cytosolic Ca2+ in rat adipocytes and suggested that membrane Ca2+ channels might be decreased. Measurement of L-type Ca2+ channels in purified plasma membranes by immunoassay or dihydropyridine binding indicated a two- to fourfold(More)
Hormone and neutrotransmitter receptor systems regulate both the activity and expression of GTP-binding proteins (G-proteins). However, relatively little is known about the mechanism by which this regulation occurs. One G-protein subtype, Gi alpha 1, is expressed primarily in neuronal cells. Here, we demonstrate the selective regulation of Gi alpha 1 mRNA(More)