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Abstract. Glycogen synthase kinase-3β (GSK-3β) is a physiological kinase for tau and is a candidate protein kinase involved in the hyperphosphorylation of tau present in paired helical filamentContinue Reading
  • Allal Boutajangout, Michéle Authelet, Véronique Blanchard, Nathalie Touchet, Jean-Pierre Brion
  • Biology, Medicine
  • Neurobiology of Disease
  • 1 February 2004
  • To study the role of Abeta amyloid deposits in the generation of cytoskeletal lesions, we have generated a transgenic mouse line coexpressing in the same neurons a wild-type human tau isoform (0N3R),Continue Reading