Michèle Malassis-Séris

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Mouse gut intraepithelial lymphocytes (IEL) consist mainly (90%) of two populations of CD8+ T cells. One bears heterodimeric alpha/beta CD8 chains (Lyt-2+, Lyt-3+), a T cell receptor (TCR) made of(More)
The small bowel mucosa contains within its villus epithelium a large number of intraepithelial lymphocytes (IEL) which upon activation are cytotoxic and release large quantities of IFN-gamma and TNF;(More)
The presence of transcripts of the recombination activating gene RAG-1 was studied by in situ hybridization on selected populations of murine thymocytes, peripheral lymphocytes and gut(More)
Mouse gut intraepithelial lymphocytes (IEL), whether thymodependent (CD4+ or CD8 cl/(3+ ; TCR-a/(3 + ) or thymoindependent (CD8 a/a+ ; TCR-ac/R+ or -y/6+), all display cytotoxic activity in a(More)
Patients with mutations in the Artemis gene display a complete absence of T- and B lymphocytes, together with increased cellular radiosensitivity; this leads to a radiosensitive severe combined(More)