Michèle Cormarèche-Leydier

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1. Subcutaneous injection of capsaïcin (6–11 mg, or 21–66 mg cumulative), permanently reduced the capacity of rats to withstand a hot environment, as described by Jancsó-Gábor et al. (1970). 2. The treated rats thermoregulatory behaviour was not different from that of control rats, both in hot and cold environments. 3. Saliva secretion was decreased in a(More)
In rats, we tested the hypothesis that capsaicin desensitization reduces hypothalamic warm thermosensitivity. We locally heated and cooled the hypothalamus using water-perfused thermodes while observing thermoregulatory variables. In untreated rats, a small dose of capsaicin had profound effects on thermoregulation. However, desensitizing rats to capsaicin(More)
Seventeen Sprague Dawley rats received, subcutaneously, 250 mg·kg−1 of capsaicin divided into 10 increasing doses (10–50 mg·kg−1) and administered on 7 successive days. Nine controls were treated with an isotonic saline solution using the same protocol. The rats spent, in succession, 5 weeks at 20° C, 6 weeks at 33.5° C, 6 weeks at 8° C, 4 weeks at 30° C(More)
1 .Subcutaneous injections of capsaicin (mean cumulative dose: 80.1±3.6 mg·kg−1) permanently reduced the capacity of rats to withstand a hot environment when deprived of water. With water available, hyperthermia was discrete or absent in capsaicinized rats in hot environment. 2. Desensitization was followed by a significant decrease in both food intake and(More)
3 dogs could behaviourally modify their own spinal cord temperature (Tspin. cord). In a hot environment, 2 dogs did not cool their spinal cord, 1 dog warmed it. The higher the environmental temperature, the higher the chosen Tspin. cord. These results seem to imply that this latter dog tended, in warm environment, to behaviourally reduce: Ts>Tspin. cord (Ts(More)
Thermodes were chronically implanted in the epidural space of 3 dogs. The dogs had learned to turn on a fan or infra-red lamps by making a voluntary head movement, in a climatic chamber. Their thermoregulatory behavior was therefore quantitatively measured. Thermal stimulation of the spinal cord was achieved by perfusing water through the spinal thermode.(More)
Capsaicin is described as disturbing the autonomic responses to stress-inducing environments. The effects of capsaicin (130 mg/kg in 2 series of subcutaneous injections) on emotionality responses were studied in 19 Sprague-Dawley male rats using the open-field test. Eleven rats treated with isotonic saline served as controls. Emotionality (E) measured(More)
Rats with a chronic thermode implanted in their spinal canal could bar-press to warm or cool their spinal cord. With a "cold" lever, they cooled their spinal canal less in a cold environment than in a warm environment. With a "warm" lever they behaved in the same way, i.e., warmed their spinal canal more in a warm than in a cold environment. In a two-lever(More)
In 7 frogs (Rana esculenta) weighing 70 to 180 g, thermopreferendum (Thp), measured by recording cutaneous temperature (Ts) in the animal placed in the warm end of an aqueous temperature gradient (0 degree C-40 degrees C), equalled 25 +/- 2 degrees C. After an intraperitoneal (IP) injection of 20 mg/kg of capsaicin, Thp was significantly decreased and(More)