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The endoplasmic reticulum (ER) forms a network of tubules and sheets that requires homotypic membrane fusion to be maintained. In metazoans, this process is mediated by dynamin-like guanosine triphosphatases (GTPases) called atlastins (ATLs), which are also required to maintain ER morphology. Previous work suggested that the dynamin-like GTPase Sey1p was(More)
MOTIVATION mRNA sequences and expressed sequence tags represent some of the most abundant experimental data for identifying genes and alternatively spliced products in metazoans. These transcript sequences are frequently studied by aligning them to a genomic sequence template. For existing programs, error-prone, polymorphic and cross-species data, as well(More)
Social tagging recommendation is an urgent and useful enabling technology for Web 2.0. In this paper, we present a systematic study of low-order tensor decomposition approach that are specifically targeted at the very sparse data problem in tagging recommendation problem. Low-order polynomials have low functional complexity, are uniquely capable of(More)
Engagement of the B cell antigen receptor initiates two concurrent processes, signaling and receptor internalization. While both are required for normal humoral immune responses, the relationship between these two processes is unknown. Herein, we demonstrate that following receptor ligation, a small subpopulation of B cell antigen receptors are inductively(More)
Given fixed budgets, companies attempt to obtain maximum coverage on a social network by targeting at influential individuals. This viral marketing is often modeled by the <i>independent cascade</i> model. However, identifying the most influential people by computing influence spread is NP-hard, and various approximate algorithms are developed. In this(More)
a r t i c l e i n f o a b s t r a c t In previous studies, the optical properties of sulfate aerosols were employed to estimate the direct radiative forcing (DRF) due to nitrate aerosols. Ensuing errors have not been rigorously evaluated, which is a major objective of this study. First, we compared the optical properties of nitrate and sulfate aerosols in(More)
The neuropsychological tests in patients with internal carotid artery (ICA) demonstrated cognitive deficits associated with frontal lobe dysfunction, but the pathophysiological mechanism of memory impairment is not fully understood. This study evaluated relationship between degree of ICA stenosis and frontal activations induced by working memory (WM) task(More)
Intrinsic functional connectivity detected by functional MRI (fMRI) provides a useful but indirect approach to study the organization of human brain systems. An unresolved question is whether functional connectivity measured by resting-state fMRI reflects anatomical connections. In this study, we used the well-characterized anatomy of cerebrocerebellar(More)
OBJECTIVE The oxidation of LDLs is considered a key step in the development of atherosclerosis. How LDL oxidation contributes to atherosclerosis remains poorly defined. Here we report that oxidized and glycated LDL (HOG-LDL) causes aberrant endoplasmic reticulum (ER) stress and that the AMP-activated protein kinase (AMPK) suppressed HOG-LDL-triggered ER(More)
BACKGROUND AND PURPOSE Although endovascular therapy (ET) is increasingly used in patients with moderate to severe acute ischemic stroke, its efficacy and safety remains controversial. We performed a meta-analysis aiming to compare the benefits and safety of endovascular treatment and intravenous thrombolysis in the treatment of acute ischemic stroke. (More)