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Molecular mechanisms underlying bone cancer pain are poorly understood. Recently, p38 mitogen-activated protein kinase (MAPK) activation was shown to play a major role not only in the production of proinflammatory cytokines but also in the progression of inflammatory and neuropathic pain. We have demonstrated that tactile allodynia and spontaneous pain of(More)
Correlations among management metrics in software systems allow errors to be detected and their cause localized. Prior research shows that linear models can capture many of these correlations. However, our research shows that several factors may prevent linear models from accurately describing correlations, even if the underlying relationship is linear. Two(More)
Stable correlation models are effective in detecting errors in complex software systems. However, most studies assume a specific mathematical form, typically linear, for the underlying correlations. In practice, more complex non-linear relationships exist between metrics. Moreover, most inter-metric correlations form clusters rather than simple pairwise(More)
Irisin is a newly discovered myokine that links exercise with metabolic homeostasis. It is involved in modest weight loss and improves glucose intolerance. However, the direct effects and mechanisms of irisin on vascular endothelial cells (ECs) are not fully understood. In the current study, we demonstrated that irisin promoted Human Umbilical Vein(More)
Ensuring high availability, adequate performance, and proper operation of enterprise software systems requires continuous monitoring. Today, most systems operate with minimal monitoring, typically based on service-level objectives (SLOs). Detailed metric-based monitoring is often too costly to use in production, while tracing is prohibitively expensive.(More)