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PURPOSE Combining tumor antigens with an immunostimulant can induce the immune system to specifically eliminate cancer cells. Generally, this combination is accomplished in an ex vivo, customized manner. In a preclinical lymphoma model, intratumoral injection of a Toll-like receptor 9 (TLR9) agonist induced systemic antitumor immunity and cured large,(More)
Electronic health record (EHR) systems store longitudinal medical data that allows for retrospective studies in healthcare. An ideal EHR would clearly designate when patient data starts and ends, allowing maximal data utility in retrospective studies. However, with differences in EHR implementation, and patients receiving treatment across many healthcare(More)
Cancer patients are often treated with multiple sequential chemotherapy protocols ranging in complexity from simple to highly complex patterns of multiple repeating drugs. Clinical documentation procedures that focus on details of single drug events, however, make it difficult for providers and systems to efficiently abstract the sequence and nature of(More)
yright © 2013 Wolters Kluwer Health | Lippincott Williams & W the medication treatment cycle. The results of research on the use of BCMA in the administration phase aremixed. This article looks at the background and challenges of using current BCMA technology to reduce medication errors that have the potential for harm. Issues will be illustrated with a(More)
Long-term adjuvant endocrine therapy patients often fail to follow-up with their care providers for the recommended duration of time. We used electronic health record data, tumor registry records, and appointment logs to predict follow-up for an adjuvant endocrine therapy patient cohort. Learning predictors for follow-up may facilitate interventions that(More)
PurposeImplementation research provides a structure for evaluating the clinical integration of genomic medicine interventions. This paper describes the Implementing Genomics in Practice (IGNITE) Network's efforts to promote (i) a broader understanding of genomic medicine implementation research and (ii) the sharing of knowledge generated in the(More)
This paper describes the ongoing development of attention, a new kind of <i>clinical decision support system</i> for synthesizing and managing longitudinal treatment plans, such as cancer treatment plans. attention combines state-of-the-art <i>formal modeling</i> and <i>constraint solving</i> with <i>clinical information systems</i> to synthesize complex(More)
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