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The asymmetric Friedel-Crafts reaction is one of the most powerful methods to synthesize optically active aromatic compounds. Particularly, the Friedel-Crafts alkylation of arenes with unsaturated compounds activated by chiral Brønsted acids provides direct access to enantiopure aromatic derivatives with perfect atom economy. In this tutorial review, recent(More)
The asymmetric Friedel–Crafts reaction is one of the most powerful methods to synthesize optically active aromatic compounds, and chiral Brønsted acids have recently emerged as efficient catalysts. Chiral phosphoric acids, first introduced by Akiyama et al. and Terada and Uraguchi as organocatalysts, were shown to be effective in the Friedel– Crafts(More)
A highly efficient tandem double Friedel-Crafts reaction between indoles and 2-formylbiphenyl derivatives by chiral N-triflyl phosphoramide was realized. Under mild conditions, various 9-(3-indolyl) fluorene derivatives have been obtained in good yield and up to 94% ee. Comparing to their corresponding chiral phosphoric acids, chiral N-triflyl(More)
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