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BACKGROUND AND PURPOSE Virtual reality (VR) is a new promising computer-assisted technology to promote motor recovery in stroke patients. VR-induced neuroplasticity supporting locomotor recovery is not known. We investigated the effects of VR intervention on cortical reorganization and associated locomotor recovery in stroke patients. METHODS Ten chronic(More)
OBJECTIVES We attempted to evaluate whether cortical activation resulting from hand movements is changed by transcranial direct current stimulation (tDCS) applied on the primary motor cortex for the hand in the human brain, using functional MRI (fMRI). METHODS Fourteen normal subjects were recruited; subjects were randomly assigned to either the tDCS(More)
OBJECTIVES Somatotopic arrangements of the corticospinal tract (CST) in the human brain have been generally elucidated; however, very little is known about the somatotopy at the medullary pyramid (MP). Using diffusion tensor tractography (DTT), we investigated the somatotopic arrangement of the CST at the MP in the normal human brain. METHODS We recruited(More)
OBJECTIVE Adipocyte fatty acid-binding protein (A-FABP) is a major cytoplasmic protein in adipocytes and macrophages and is closely associated with metabolic syndrome, type 2 diabetes, and atherosclerosis. Here, we investigated whether A-FABP was associated with nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes. RESEARCH DESIGN AND METHODS We(More)
BACKGROUND Recently, the measurement of glycated hemoglobin (HbA1c) was recommended as an alternative to fasting plasma glucose or oral glucose tolerance tests for diagnosing diabetes mellitus (DM). In this study, we analyzed HbA1c levels for diabetes mellitus screening in a Korean rural population. METHODS We analyzed data from 10,111 subjects from a(More)
It is well documented that manganese neurotoxicity induces clinical symptoms similar to those of idiopathic Parkinson's disease. Although microglial cytotoxic mediator-induced neurotoxicity is suggested, the mechanism by which manganese up-regulates cytotoxic mediator, such as nitric oxide (NO), remains poorly understood. Therefore, in this study, we(More)
In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: Keywords: Iterative methods Order of convergence Rational maps Basin of attraction(More)
Active execution, proprioception, and touch discrimination are important for the execution of movement. In the current study, we attempted to compare the cortical activation patterns of active exercise, proprioceptive input, and touch stimulation in the normal human brain using functional MRI. Nine subjects were recruited for this study. Functional MRI was(More)
BACKGROUND Mitochondrial dysfunction has been implicated in neuronal apoptosis associated with neurodegenerative diseases such as Huntington's disease (HD). Animals that are administered 3-nitropropionic acid (3-NP), a mitochondrial toxin that specifically inhibits complex II of the mitochondrial electron transport chain, manifest HD-like symptoms. (More)
Little is known about the recovery mechanism of somatosensory function in thalamic hemorrhage. We investigated the recovery mechanism of somatosensory function, using functional MRI (fMRI) findings by proprioceptive input in chronic patients with thalamic hemorrhage. Eleven consecutive chronic patients with thalamic hemorrhage who showed severe(More)