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FGF2-induced chromatin remodeling regulates CNTF-mediated gene expression and astrocyte differentiation
It is found that fibroblast growth factor 2 (FGF2), which by itself does not induce astrocyte-specific gene expression, regulates the ability of CNTF to induce expression of glial fibrillary acidic protein (GFAP).
T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration
This study suggests that Tbx20 programs a variety of hindbrain motor neurons for migration, independent of directionality, and in facial neurons is a positive regulator of the non-canonical Wnt signaling pathway.
Sphingosine 1-phosphate receptor subtype 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization
This study identified S1P3 as a pathogenic mediator in an ischemic brain along with underlying mechanisms, involving its modulation of microglial activation and M1 polarization, further suggesting that S 1P3 can be a therapeutic target for cerebral ischemia.
Islet-to-LMO stoichiometries control the function of transcription complexes that specify motor neuron and V2a interneuron identity
Although LIM-only proteins (LMOs) are predicted to antagonize the function of Islet proteins, it is found that the presence or absence of Lmo4 had little influence on MN or V2a IN specification, and the loss of MNs resulting from reduced Islet levels was rescued by eliminating Lmo 4, unmasking a functional interaction between these proteins.
Isl1 Is required for multiple aspects of motor neuron development
The complex morphology of reactive astrocytes controlled by fibroblast growth factor signaling
Results indicate that FGF8–FGFR3 signaling controls structural changes in astrocytes during reactive gliosis, under pathogenic conditions.
Functional Diversification of Motor Neuron-specific Isl1 Enhancers during Evolution
It is reported that transcription of Isl1, a major gene necessary for motor neuron identity, is controlled by two enhancers, CREST1 (E1) and CREST2 (E2) that allow selective gene expression of IsL1 in motor neurons.