Mi-Hyun Cho

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MN/CA9 is a cancer-related gene, frequently activated in human renal cell carcinomas (RCCs). To reveal the activation mechanism, we investigated the relationship between methylation status of the MN/CA9 promoter region and gene expression using 13 human RCCs, and examined the effect of in vitro CpG methylation on the MN/CA9 promoter activity using a human(More)
has become the second and third leading cause of cancer death in men, respectively (Boring et al, 1993; Black et al, 1997). Associated mortality in Japan has also increased in recent years with the Westernization of dietary habits (Tominaga and Kuroishi, 1997). The continuing controversy as to whether PSA-based screening and early detection of prostate(More)
Specificity protein 1 (SP1) is an essential transcription factor that regulates multiple cancer-related genes. Because aberrant expression of SP1 is related to cancer development and progression, we focused on SP1 expression in gastric carcinoma and its correlation with disease outcomes. Although patient survival decreased as SP1 expression increased(More)
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