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Electronic structure calculations have become an indispensable tool in many areas of materials science and quantum chemistry. Even though the Kohn-Sham formulation of the density-functional theory (DFT) simplifies the many-body problem significantly, one is still confronted with several numerical challenges. In this article we present the projector(More)
The design, synthesis, and pharmacological characterization of a highly potent and selective glutamate GluR5 agonist is reported. (S)-2-Amino-3-((RS)-3-hydroxy-8-methyl-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid (5) is the 8-methyl analogue of (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid ((S)-4-AHCP, 4).(More)
  • De Jonge, Rosmalen, Jgm Kema, Ip Wust, S Van Der Ley, C Visser +29 others
  • 2015
"Critical slowing down in depression" is a great idea that still needs empirical proof 24 h urinary free cortisol in large-scale epidemiological studies: Short-term and long-term stability and sources of variability A manual-based individual therapy to improve metacognition in schizophrenia: protocol of a multi-center RCT A randomized controlled study of a(More)
We have constructed stable HEK293 cell lines expressing the rat ionotropic glutamate receptor subtypes GluR1(i), GluR2Q(i), GluR3(i), GluR4(i), GluR5Q and GluR6Q and characterised the pharmacological profiles of the six homomeric receptors in a fluorescence-based high throughput screening assay using Fluo-4/AM as a fluorescent Ca2+ indicator. In this assay,(More)
PURPOSE This prospective study aimed to evaluate unilateral versus bilateral mandibular nerve block anesthesia with regard to post-operative soft tissue trauma and other complications in a pediatric population. METHODS A total of 320 patients age 2 to 18 years were appointed for routine operative treatment. There were no age, gender, behavior, or general(More)
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