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Changing the protein source of fish feed from fish meal to alternative sources of protein will affect traits such as fish growth, quality, and feed utilization. The present investigation was initiated to introduce a two-dimensional gel electrophoresis based proteomic workflow as a tool to investigate feed effects on fish by analyzing protein changes in the(More)
Eight pre-concentration techniques were compared for their capacity to retain volatile and semi-volatile solutes during evaporation of solvent (dichloromethane). The 2-ml test-samples containing 0.2 ppm or 2 ppm (v/v) of volatile and semi-volatile solutes were concentrated to a final volume of 1 ml, 200 microl and 50 microl, respectively. When(More)
Mycophenolate mofetil (MMF) is a prodrug immunosuppressant with a high oral bioavailability. Enterohepatic cycling of a glucuronide derivative of MMF contributes substantially to the bioavailability, but is dependent on bacterial deglucuronidation by intestinal flora. This study aims to determine whether an antibiotic regimen with activity against such(More)
In the present study, we used a proteomic approach to identify surface-associated proteins from the probiotic bacterium Lactobacillus plantarum 299v. Proteins were extracted from the cell surface using a mild wash in phosphate buffer and analysed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis. Gel bands were excised and in-gel digested with(More)
Multivariate data analysis has been combined with proteomics to enhance the recovery of information from 2-DE of cod muscle proteins during different storage conditions. Proteins were extracted according to 11 different storage conditions and samples were resolved by 2-DE. Data generated by 2-DE was subjected to principal component analysis (PCA) and(More)
Frozen storage of fish is known to enhance lipid oxidation, resulting in the development of an unpleasant rancid taste and odor. Frozen storage of fish is also known to reduce protein solubility, and proteins are expected to be oxidatively modified; however, these oxidative mechanisms are poorly understood. Generally, protein oxidation leads to a wide range(More)
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