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  • M Heringa
  • 2003
Raloxifene is a selective estrogen receptor modulator approved for prevention and treatment of osteoporosis in postmenopausal women. Raloxifene has an estrogen-agonistic effect on bone, although it is unclear how this effect comes about. It has been proven that raloxifene decreases levels of both bone formation markers and bone resorption markers in(More)
AIMS To compare raloxifene pharmacokinetics between renally impaired and healthy subjects. METHODS Raloxifene 120 mg was administered to 10 males with renal impairment (creatinine 2-4 mg dl(-1)) and to 10 healthy males. Data were analysed by two noncompartmental and one compartmental nonlinear regression methods. RESULTS The medians (95% confidence(More)
OBJECTIVE To introduce the pathophysiological Tulip classification system for underlying cause and mechanism of perinatal mortality based on clinical and pathological findings for the purpose of counselling and prevention. DESIGN Descriptive. SETTING Tertiary referral teaching hospital. POPULATION Perinatally related deaths. METHODS A classification(More)
We decided to assess the practicability of introducing nuchal translucency (NT) measurements as a screening programme for fetal Down's syndrome in the first trimester of pregnancy, within the population of women who receive ultrasound examinations in our department. Over a 1-year period, measurements were made in 923 fetuses at < or = 13 weeks' gestation.(More)
The antenatal screening practice of 67 teaching hospitals in the European Community was assessed by use of a written questionnaire. There were minor differences in mean numbers of tests performed in different countries, but only limited agreement was found on the selection of tests that were performed. There was no unity of practice within the countries. No(More)
OBJECTIVE To examine the association between hypertensive disorders of pregnancy and second-trimester maternal serum alpha-fetoprotein (MSAFP) and hCG levels. METHODS The proportions of abnormal second-trimester MSAFP and hCG levels in the serum samples from 65 women with true pregnancy-induced hypertension or preeclampsia (cases) were compared to the(More)
For the benefit of pre-embryonal research, women requesting sterilization may be asked whether they are prepared to donate egg cells. Recently, a questionnaire was sent to 144 women who had given birth to their second or third child at the University Hospital Groningen, asking them how they felt about egg cell donation: 68 (47%) of the questionnaires was(More)
OBJECTIVE To compare the actual situation in tertiary perinatal care in the Netherlands with the objectives laid down in the 2001 decree on perinatal care by the Dutch Ministry of Health, Welfare and Sport. DESIGN Descriptive, retrospective. METHOD Data on tertiary perinatal care, the transfer or refusal of women with very endangered pregnancies and the(More)
OBJECTIVE Analysing the course and outcome of pregnancies in liver transplant recipients. DESIGN Retrospective and descriptive. METHOD Since 1979 liver transplantations have been performed in the University Hospital Groningen, the Netherlands. Seven female patients conceived 12 times after transplantation. These pregnancies were managed by a team of(More)