Mette Ebbesen

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Nanotechnology is concerned with materials and systems whose structures and components exhibit novel physical, chemical, and biological properties due to their nanoscale size. This paper focuses on what is known as nanomedicine, referring to the application of nanotechnology to medicine. We consider the use and potentials of emerging nanoscience techniques(More)
Bioethical research has tended to focus on theoretical discussion of the principles on which the analysis of ethical issues in biomedicine should be based. But this discussion often seems remote from biomedical practice where researchers and physicians confront ethical problems. On the other hand, published empirical research on the ethical reasoning of(More)
BACKGROUND This study presents an empirical investigation of the ethical reasoning and ethical issues at stake in the daily work of physicians and molecular biologists in Denmark. The aim of this study was to test empirically whether there is a difference in ethical considerations and principles between Danish physicians and Danish molecular biologists, and(More)
RNA interference is a mechanism for controlling normal gene expression which has recently begun to be employed as a potential therapeutic agent for a wide range of disorders, including cancer, infectious diseases and metabolic disorders. Clinical trials with RNA interference have begun. However, challenges such as off-target effects, toxicity and safe(More)
BACKGROUND This article presents results from a qualitative empirical investigation of how Danish oncology physicians and Danish molecular biologists experience the principle of respect for autonomy in their daily work. METHODS This study is based on 12 semi-structured interviews with three groups of respondents: a group of oncology physicians working in(More)
Bulletin of Science, Technology & Society Vol. 26, No. 6, December 2006, 451-462 DOI: 10.1177/0270467606295003 Copyright © 2006 Sage Publications Research in nanotechnology has advanced rapidly in recent years. Several researchers, however, warn that there is a paucity of research on the ethical, legal, and social implications of nanotechnology, and they(More)
In clinical trials on age-related macular degeneration, small interfering RNAs (siRNAs) targeting vascular endothelial growth factor or its receptor are used to inhibit angiogenesis. However, novel data suggests that certain siRNA molecules can act unspecifically, without even entering a cell. The sequence- and target-independent suppression of the(More)
Neurodegenerative diseases are characterized by loss of neurons in the brain or the spinal cord. They include diseases such as Alzheimer disease, Huntington disease, and Parkinson disease, for which no effective treatments have been found. These severe diseases lead to loss of life quality for affected individuals and large health care costs for society.(More)
The American ethicists Tom L. Beauchamp and James F. Childress developed a framework of four ethical principles which are useful to analyze ethical complex cases in biomedicine. These four principles are respect for autonomy, beneficence, nonmaleficence, and justice. Beauchamp and Childress believe that their approach to manage ethical difficult cases is(More)
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