Messanvi F Gbeassor

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Extracts of 22 species of Meliaceae were examined for antimalarial activity using in vitro tests with two clones of Plasmodium falciparum, one sensitive to chloroquine (W2) and one chloroquine-resistant (D6). Twelve extracts were found to have activity, including extracts of Cedrela odorata wood and Azadirachta indica leaves, which contained the limonoid(More)
A bioassay-guided isolation of antifungal compounds from an African land race of ginger, Zingiber officinale Roscoe, led to the identification of [6], [8] and [10]-gingerols and [6]-gingerdiol as the main antifungal principles. The compounds were active against 13 human pathogens at concentrations of <1 mg/mL. The gingerol content of the African land race(More)
BACKGROUND Malaria continues to be of great concern in Togo, as it accounts for high mortality rates, principally in children. Although plant-based medicines are the only means in major malarious regions of the country, still very little is known about the medicinal plants and medical practices of the indigenous people. OBJECTIVE The present study aimed(More)
AIM OF THE STUDY In Africa, medicinal plants are used intensively and concomitantly with allopathic medicines in the treatment of opportunity diseases by many patients or by healthy person to prevent diseases. However, there is little information about the interactions between medicines and botanical products used currently in West Africa area. Therefore,(More)
Five species of Combretaceae growing in Togo were investigated for their antifungal activity against 20 pathogenic fungi (10 yeast and 10 filamentous fungi). The five hydroethanolic extracts of Terminalia glaucescens and Anogeissus leiocarpus appeared to be the most active, their MICs ranging from 0.25 mg/ml to 4 mg/ml. The results confirm the traditional(More)
The effects of three compounds, digitolutein (1), rubiadin 1-methyl ether (2) and damnacanthal (3) extracted from the stem bark and the roots of Morinda lucida Benth. on the growth of Plasmodium falciparum in vitro were investigated. The number of parasites (schizonts) decreased significantly in a dose-dependent manner, and 100% of inhibition was obtained(More)
Traditional oral report indicates that Tectona grandis is used in the treatment of anaemia in Togo. For this purpose, the extract of T. grandis leaves is evaluated on anaemia model of rat induced by intraperitoneal injection of phenylhydrazine at 40 mg/kg for 2 days. Oral administration of T. grandis extract at 1 g/kg/day and 2 g/kg/day, to the rats(More)
Methanol extracts were prepared from 19 medicinal plants of Togo and, by means of standard laboratory tests, were analysed for antiviral and antibiotic activities. Ten of the 19 showed significant antiviral activity and all but two displayed antibiotic activity. Extracts of three species, Adansonia digitata (the most potent), Conyza aegyptiaca and Palisota(More)
The essential oil of Lippia multiflora Moldenke (Verbenaceae) produced by conventional hydrodistillation was analyzed and studied for its analgesic, antipyretic and anti-inflammatory activities in rats and mice. At the doses used (2, 4 and 8 ml/kg o.s.) the essential oil of L. multiflora showed significant and dose-dependent analgesic effect on acetic(More)
Les effets antipaludiques des extraits de trois plantes de la pharmacopée traditionnelle congolaise, Cassia siamea, Cassia spectabilis, Tetracera alnifolia (sélectionnées à partir d’une enquête ethnobotanique), ont été étudiés chez des malades (20 pour chaque extrait) présentant une goutte épaisse positive et une hyperthermie. Les grandes familles chimiques(More)