Mervyn A Williams

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The Intact porcine bioprosthesis became available for clinical use in 1984. The device incorporates three innovations aimed at reducing calcification and improving durability. Between October 1984 and March 1988, 221 valves were implanted in 200 patients. Sixty-two valves were implanted in the aortic position, 155 valves in the mitral position, and 4 valves(More)
A previously unreported combination of critical pulmonary valve stenosis and mitral stenosis is described. The initial clinical presentation was one of right ventricular failure that obscured the evidence of pulmonary venous hypertension. Following pulmonary valvulotomy, pulmonary edema ensued because of the increased pulmonary blood flow. The importance of(More)
The INTACT (previously Xenotech) valve incorporates three major departures from previously available bioprostheses. The following innovations are aimed at reducing calcification and improving durability: (1) the stent has a high profile configuration and the sinuses are deeply excavated. This should maintain normal coaption of the leaflets and prevent cusp(More)
BACKGROUND This study was undertaken to evaluate the clinical performance of the Carbomedics, Medtronic Hall and On-X valves in the challenging setting of a Third World population with incomplete anticoagulation coverage. METHODS In the Carbomedics group 140 valves were implanted in 126 patients (aortic 30, mitral 82, and aortic and mitral 14), 39% were(More)
BACKGROUND AND AIM OF THE STUDY The study aim was to evaluate the clinical performance of the On-X heart valve in a socioeconomically disadvantaged population. Most patients were from an indigenous, poorly educated and geographically dispersed segment of the population where anticoagulation therapy was generally erratic. METHODS Between 1999 and 2004, a(More)
Between 1984 and 1987, tissue valves were used for valve replacement in 37 patients less than 20 years of age. In 26 patients, porcine valves were used and in 11 patients, antibiotic sterilized allografts were used. Follow-up of these patients is from 3 to 6 years. In the xenograft series, 13 patients developed documented calcific stenosis of the valve(More)
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