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Using gene targeting in embryonic stem cells, we have derived mice with a null mutation in a DNA mismatch repair gene homolog, PMS2. We observed microsatellite instability in the male germline, in tail, and in tumor DNA of PMS2-deficient animals. We therefore conclude that PMS2 is involved in DNA mismatch repair in a variety of tissues. PMS2-deficient(More)
Caenorhabditis elegans locomotion is a complex behavior generated by a defined set of motor neurons and interneurons. Genetic analysis shows that UNC-43, the C. elegans Ca(2+)/calmodulin protein kinase II (CaMKII), controls locomotion rate. Elevated UNC-43 activity, from a gain-of-function mutation, causes severely lethargic locomotion, presumably by(More)
In C. elegans, a G(o)/G(q) signaling network regulates locomotion and egg laying [1-8]. Genetic analysis shows that activated Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is suppressed by perturbations of this network, which include loss of the GOA-1 G(o)alpha, DGK-1 diacylglycerol kinase, EAT-16 G protein gamma subunit-like (GGL)-containing RGS(More)
Genetic analysis indicates that the gene eat-11 is involved locomotion and egg laying [1–8]. Genetic analysis shows that activated Ca 2؉ /calmodulin-dependent in the GOA-1 G o ␣/EGL-30 G q ␣ signaling network (Figure 1a; [3, 9]). To determine the molecular identity of eat-protein kinase II (CaMKII) is suppressed by perturbations of this network, which(More)
This study was designed to determine whether ectomycorrhizal mats (ECM) are more likely to be present in soils at the base of common understory trees than in soils distant from trees and to determine whether occurrence of ECM is related to tree size. Three understory trees were studied: Pacific yew (Taxus brevifolia Nutt.), western hemlock (Tsuga(More)
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