Merja Kokki

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PURPOSE To evaluate postoperative pain and early recovery in cataract patients. PATIENTS AND METHODS A total of 201 patients who underwent elective first eye cataract extraction surgery were enrolled, and 196 were included in the final analysis. The study design was a single-center, prospective, follow-up study in a tertiary hospital in eastern Finland.(More)
To characterize the pharmacokinetics (PK) of oxycodone following intravenous injection and administration of three oral dosage forms (solution, capsule, and controlled-release tablet) in elderly patients (age 76–89 years) undergoing cystoscopy. This was an open, randomized study with two sequences and two visits in 15 elderly patients. The patients were(More)
Dear Editor Cyclic oligosaccharides, cyclodextrins, are increasingly used in clinical practice [1]. A chemically modified γ-cyclodextrin consisting of eight glucopyranose units, sugammadex, is used to reverse neuromuscular blockade induced with rocuronium and other aminosteroid neuromuscular agents. The mode of action of sugammadex is unique: chelation of(More)
BACKGROUND AND OBJECTIVES Oxycodone is the mo st commonly used opioid for the treatment of moderate to severe pain. The peak cerebrospinal fluid concentration after epidural oxycodone was reported to be 300-fold greater (0.025 mM) than when administered intravenously after gynecologic surgery. Additionally, those patients administered epidural oxycodone had(More)
INTRODUCTION Opioids are needed for postoperative pain in spine surgery patients, but opioid-induced constipation is a harmful adverse event. The aim of this clinical trial was to compare the use of a controlled-release oxycodone-naloxone combination product with oxycodone controlled-release tablets in these patients. The main outcome measure was the(More)
The aim of the current population pharmacokinetic study was to quantify oxycodone pharmacokinetics in children ranging from preterm neonates to children up to 7 years of age. Data on intravenous or intramuscular oxycodone administration were obtained from three previously published studies (n = 119). The median [range] postmenstrual age of the subjects was(More)
INTRODUCTION Sufentanil is a highly selective µ-opioid agonist commonly used by intravenous and intrathecal routes for acute pain. Sublingual sufentanil formulation for patient controlled analgesia (PCA) uses an innovative administration device that suspends a 15 µg nanotablet with a fixed lockout interval. The system is a non-invasive, less burdensome(More)
BACKGROUND Several factors are thought to affect the spread and duration of spinal anesthesia (SA) in adults. These include the volume of cerebrospinal fluid (CSF) in the lumbar spinal canal, which has a negative correlation with both the spread and duration of the sensory block. OBJECTIVES We evaluated whether CSF aspiration before an injection of(More)
[1]. We totally agree with Parsons that the choice of appropriate cell model is of paramount importance in in vitro drug toxicity testing [2]. Moreover, using at least two cell lines and two toxicity assays is endorsed in order to have more accurate and relevant interpretation of drug toxicity for clinical use. In our study, we have used the SH-SY5Y and(More)
BACKGROUND Data on the association of memory performance with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are inconsistent. The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-NB) is a commonly used validated cognitive tool; however, only few studies have examined its relationship with CSF(More)