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Mutualism, a beneficial relationship between two species, often requires intimate interaction between the host and symbiont to establish and maintain the partnership. The colonial marine bryozoan Bugula neritina harbors an as yet uncultured endosymbiont, "Candidatus Endobugula sertula," throughout its life stages. The bacterial symbiont is the putative… (More)
An interesting approach to study the metabolic differences between species is metabolic pathway. In this study, we characterize pathways activity levels of two samples. We applied our proposed methods on RNA-Seq Bugula neritina metage-nomics data. We successfully identified several differential pathway activity and we selected 3 of them for qPCR validation.
Assessing pathway activity levels is a plausible way to quantify metabolic differences between various conditions. This is usually inferred from microarray expression data. Wide availability of NGS technology has triggered a demand for bioinformatics tools capable of analyzing pathway activity directly from RNA-Seq data. In this paper we introduce XPathway,… (More)
The design and synthesis of novel SGLT2 inhibitors: C-Glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties, " Access to 3-arylindoles through a tandem one-pot protocol involving dearomatization, a regioselective Michael addition reaction, and rearomatization,
The colonial marine bryozoan, Bugula neritina, harbors an uncultured endosymbiont, " Candidatus Endobugula sertula " throughout its life stages. The bacterial symbiont has been proposed to be a source of complex polyketide metabolites, the bryostatins, that chemically defend B. neritina larvae from predation. Within a bryozoan colony, significantly higher… (More)