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An interesting approach to study the metabolic differences between species is metabolic pathway. In this study, we characterize pathways activity levels of two samples. We applied our proposed methods on RNA-Seq Bugula neritina metage-nomics data. We successfully identified several differential pathway activity and we selected 3 of them for qPCR validation.
The design and synthesis of novel SGLT2 inhibitors: C-Glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties, " Access to 3-arylindoles through a tandem one-pot protocol involving dearomatization, a regioselective Michael addition reaction, and rearomatization,
Assessing pathway activity levels is a plausible way to quantify metabolic differences between various conditions. This is usually inferred from microarray expression data. Wide availability of NGS technology has triggered a demand for bioinformatics tools capable of analyzing pathway activity directly from RNA-Seq data. In this paper we introduce XPathway,… (More)
The colonial marine bryozoan, Bugula neritina, harbors an uncultured endosymbiont, " Candidatus Endobugula sertula " throughout its life stages. The bacterial symbiont has been proposed to be a source of complex polyketide metabolites, the bryostatins, that chemically defend B. neritina larvae from predation. Within a bryozoan colony, significantly higher… (More)