• Publications
  • Influence
Remarkably different structures and reaction mechanisms of ketoreductases for the opposite stereochemical control in the biosynthesis of BIQ antibiotics.
Two ketoreductases, RED1 and RED2, are involved in the biosynthesis of actinorhodin in Streptomyces coelicolor A3(2) and dihydrogranaticin in S. violaceoruber Tu22, respectively. They are responsibleExpand
  • 16
  • 3
Fluorous phase chemistry: a new industrial technology
The fluorous biphasic system has become increasingly popular amongst the academic community as a phase separation and immobilisation technique. It has revolutionised both the synthetic organic andExpand
  • 92
  • 1
Steroidomimetic Tetrahydroisoquinolines for the Design of New Microtubule Disruptors
Structure–activity relationship translation offers an expeditious means for discovery of new active series. This approach was applied to discover tetrahydroisoquinoline (THIQ)-based steroidomimeticExpand
  • 25
  • 1
Actinorhodin biosynthesis: structural requirements for post-PKS tailoring intermediates revealed by functional analysis of ActVI-ORF1 reductase.
Actinorhodin (ACT) produced by Streptomyces coelicolor A3(2) is an aromatic polyketide antibiotic, whose basic carbon skeleton is derived from type II polyketide synthase (PKS). Although an acylExpand
  • 22
Enantioselective reduction of beta-keto acids with engineered Streptomyces coelicolor.
  • 5
Abstract #5562: Discovery of tetrahydroisoquinoline based microtubule disrupting agents with in vivo anti-angiogenic activity
AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO Previously, we developed a series of steroidal derivatives as dual inhibitors of cancer cell proliferation and angiogenesis and have now exploredExpand