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Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma
Intermittent intense ultraviolet (UV) exposure represents an important aetiological factor in the development of malignant melanoma. The ability of UV radiation to cause tumour-initiating DNA… Expand
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation
Adoptive cell transfer therapies (ACTs) with cytotoxic T cells that target melanocytic antigens can achieve remissions in patients with metastatic melanomas, but tumours frequently relapse.… Expand
Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c‐MET Limit Cancer Immunotherapy
&NA; Inhibitors of the receptor tyrosine kinase c‐MET are currently used in the clinic to target oncogenic signaling in tumor cells. We found that concomitant c‐MET inhibition promoted adoptive T… Expand
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion.
- C. Frangieh, Johannes C Melms, +19 authors Benjamin Izar
- Biology, Medicine
- Nature genetics
- 1 March 2021
Resistance to immune checkpoint inhibitors (ICIs) is a key challenge in cancer therapy. To elucidate underlying mechanisms, we developed Perturb-CITE-sequencing (Perturb-CITE-seq), enabling pooled… Expand
A single-cell landscape of high-grade serous ovarian cancer
Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor prognosis 1 . To… Expand
A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells.
Human melanomas exhibit considerable genetic, pathologic, and microenvironmental heterogeneity. Genetically engineered mice have successfully been used to model the genomic aberrations contributing… Expand
A stochastic model for immunotherapy of cancer
We propose an extension of a standard stochastic individual-based model in population dynamics which broadens the range of biological applications. Our primary motivation is modelling of… Expand
Inhibition of Haspin kinase promotes cell-intrinsic and extrinsic anti-tumor activity.
- Johannes C Melms, S. Vallabhaneni, +21 authors Benjamin Izar
- Biology, Medicine
- Cancer research
- 27 December 2019
Melanoma patients resistant to RAF/MEK-inhibitors (RMi) are frequently resistant to other therapies, such as immune checkpoint inhibitors (ICI), and individuals succumb to their disease. New drugs… Expand
Multi-modal pooled Perturb-CITE-Seq screens in patient models define novel mechanisms of cancer immune evasion
Resistance to immune checkpoint inhibitors (ICI) that activate T cell mediated anti-tumor immunity is a key challenge in cancer therapy, yet the underlying mechanisms remain poorly understood. To… Expand
A preclinical model of malignant peripheral nerve sheath tumor-like is characterized by infiltrating mast cells
Human melanomas exhibit considerable genetic, pathological, and microenvironmental heterogeneity. Genetically engineered mice have successfully been used to model the genomic aberrations contributing… Expand