Merel Bakker

Learn More
OBJECTIVES To evaluate nasal bone length (NBL), prenasal thickness (PT), prenasal thickness-to-nasal bone length (PT-NBL) ratio and prefrontal space ratio (PFSR) as markers for Down syndrome in the second and third trimesters. METHODS NBL, PT, PT-NBL ratio and PFSR were measured retrospectively in stored two-dimensional images or three-dimensional volumes(More)
OBJECTIVE The aim of this study was to evaluate which of the following factors affect the uptake of the combined test (CT) in The Netherlands: women's socio-demographic background, attitude towards Down syndrome, attitude towards termination of pregnancy, counseling process, reimbursement policy, and knowledge on the aim of the CT. METHODS Cross-sectional(More)
OBJECTIVE To identify pregnancy-related risk factors for different manifestations of congenital anorectal malformations (ARMs). DESIGN A population-based case-control study. SETTING Seventeen EUROCAT (European Surveillance of Congenital Anomalies) registries, 1980-2008. POPULATION The study population consisted of 1417 cases with ARM, including 648(More)
CHARGE syndrome is a multiple congenital anomaly syndrome that can be life-threatening in the neonatal period. Complex heart defects, bilateral choanal atresia, esophageal atresia, severe T-cell deficiency, and brain anomalies can cause neonatal death. As little is known about the causes of death in childhood and adolescence, we studied post-neonatal death(More)
OBJECTIVE To investigate the influence of ethnicity on the awareness and use of folic acid by pregnant women. DESIGN Secondary data analysis. METHOD Using the data on 1555 women, collected during a cross-sectional study conducted among pregnant women with good knowledge of the Dutch language in 1996, the authors determined what was known about the(More)
OBJECTIVE Aim of the study was to assess the percentage and type of anomalies (structural and chromosomal) that can be detected at an early scan performed at 12-13 weeks' gestation, as opposed to the present screening policy (20 -week scan). METHODS Sonographers accredited for the nuchal translucency (NT) measurement were asked, after additional training,(More)
OBJECTIVE To assess the public health consequences of the rise in multiple births with respect to congenital anomalies. DESIGN Descriptive epidemiological analysis of data from population-based congenital anomaly registries. SETTING Fourteen European countries. POPULATION A total of 5.4 million births 1984-2007, of which 3% were multiple births. (More)
OBJECTIVE The objective of this article is to investigate whether in the clinical setting of second trimester ultrasound (US) investigations, 3D multiplanar correction prior to the measurement of Down syndrome (DS) facial markers (nasal bone length, prenasal thickness, fetal profile line, maxilla-nasion-mandible angle, prenasal thickness to nasal bone(More)
Over the years, it has become clear that increased nuchal translucency is a marker for chromosomal abnormalities, and it is also associated with a wide spectrum of structural anomalies, genetic syndromes, a higher risk of miscarriage, and intrauterine fetal death. These risks are all proportionally related to the degree of nuchal translucency enlargement.(More)
OBJECTIVE To define sonographic criteria that may improve the prenatal diagnosis of Noonan syndrome by targeted DNA testing. METHODS We searched our Fetal Medicine Unit records for all cases with a final diagnosis of Noonan syndrome. A literature review was undertaken to identify the sonographic features of Noonan syndrome fetuses. Information was pooled(More)