Mercedes Espada

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OBJECTIVE To investigate whether circulating 25-hydroxyvitamin D(3) [25(OH)D(3)] concentration in pregnancy is associated with neuropsychological development in infants. METHODS The Spanish population-based cohort study INfancia y Medio Ambiente Project recruited pregnant women during the first trimester of pregnancy between November 2003 and February(More)
Iodine is the main constituent of thyroid hormones, which in turn are required for fetal brain development. However, the relation between iodine intake during pregnancy, thyroid function, and child neurodevelopment needs further evaluation. The authors assessed the association of maternal iodine intake from diet and supplements during pregnancy and of(More)
BACKGROUND Adequate vitamin D status in mothers during pregnancy may influence the health status of the child later in life. We assessed whether maternal circulating 25-hydroxyvitamin D (25[OH]D) concentrations in pregnancy are associated with risk of lower respiratory tract infections, wheezing, and asthma in the offspring. METHODS Data were obtained(More)
INTRODUCTION Several epidemiological studies have reported that some organochlorine compounds (OCs), such as polychlorobiphenyls (PCBs) and 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (4,4'-DDE), may alter thyroid function. OBJECTIVE The aim of the present study was to investigate the association of maternal serum OC concentrations of 4,4'-DDE and the(More)
The effect of organochlorine compounds (OCs) on thyroid function, as well as the potential confounding effect of iodine intake, was studied in a large sample of pregnant women from two population-based cohort studies in Sabadell (n = 520) and Gipuzkoa (n = 570), Spain. Thyroid hormones (free T4 and total T3), thyrotropin, and polychlorinated biphenyls (PCB(More)
OBJECTIVE To investigate the association of maternal circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration with pregnancy and birth outcomes. DESIGN Prospective cohort study. SETTING Four geographical areas of Spain, 2003-2008. POPULATION Of 2382 mother-child pairs participating in the INfancia y Medio Ambiente (INMA) Project. METHODS Maternal(More)
OBJECTIVES To estimate the prevalence and factors associated with smoking and misclassification in pregnant women from INMA (INfancia y Medio Ambiente, Environment and Childhood) project, Spain, and to assess the optimal cut-offs for urinary cotinine (UC) that best distinguish daily and occasional smokers with varying levels of second-hand smoke (SHS)(More)
BACKGROUND The fetus depends on maternal thyroid hormones during pregnancy for normal brain development. Little is known about the effects of subclinical hypothyroidism and mild hypothyroxinemia during pregnancy on neurodevelopment of the child. METHODS We evaluated a population-based birth cohort in Spain. A total of 1761 children and their mothers were(More)
BACKGROUND An adequate iodine intake during pregnancy is essential for the synthesis of maternal thyroid hormones and normal brain development in the fetus. Scant evidence is available on the effects and safety of iodine supplementation during pregnancy in areas with adequate or mildly deficient iodine intake. We examined the association of maternal iodine(More)
BACKGROUND Iodine is an essential trace element for the synthesis of thyroid hormones, which are keys in maternal metabolism during pregnancy as well as in neurological development during fetal and postnatal life. This was a prospective study on iodine status and thyroid function in women during pregnancy in the Basque country to assess whether there was(More)