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BACKGROUND AND PURPOSE Free radical production after spinal cord injury (SCI) plays an important role in secondary damage. The aim of this study was to investigate neuroprotective effects of the powerful antioxidant alpha-lipoic acid (ALA) in a spinal cord clip compression injury model. MATERIAL AND METHODS Fifty-six Sprague-Dawley rats, weighing between(More)
Dear Editor, Bisphosphonates are analogs of inorganic pyrophosphate. They are potent inhibitors of osteoclast-mediated bone resorption, and are shown to be effective in reducing skeletal complications such as bone pain, pathologic fracture, bone surgery, and hypercalcemia [1–5]. Zoledronic acid is a new long-acting and highly potent biphosphonate. We report(More)
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