Menno E van der Elst

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BACKGROUND Despite the well-known beneficial effects of statins, many patients do not adhere to chronic medication regimens. OBJECTIVE To implement and assess the effectiveness of a community pharmacy-based pharmaceutical care program developed to improve patients' adherence to statin therapy. METHODS An open-label, prospective, randomized controlled(More)
BACKGROUND After market approval, new serious safety issues are regularly identified for drugs that lead to regulatory action to inform healthcare professionals. However, the effectiveness of these safety-related regulatory actions is under question. We currently lack a comprehensive overview of the effects of these drug safety warnings on clinical practice(More)
OBJECTIVE To examine the use of oral antithrombotics (i.e., antiplatelet agents, oral anticoagulants) after myocardial infarction (MI) in the Netherlands from 1988 to 1998. METHODS Retrospective follow-up of 3800 patients with MI, using data from the PHARMO Record Linkage System. RESULTS From 1988 to 1998, oral antithrombotic treatment increased(More)
OBJECTIVE To determine the effect of the number of different drugs with adherence to medication of at least 70% on recurrent admission for myocardial infarction (MI) in patients with a history of MI. DESIGN Nested case-control study in a dynamic cohort. SETTING PHARMO database that contains pharmacy dispensing records and hospital discharge records of(More)
STUDY OBJECTIVE To develop and evaluate a peer review group (PRG) meeting using feedback data on a patient level to improve the quality of drug therapy for prevention of recurrent myocardial infarction. DESIGN Prospective follow-up study. DATA SOURCE General practitioners' computerized patients records (intervention patients) and the PHARMO record(More)
This study was aimed at assessing the extent of safety learning from data pertaining to other drugs of the same class. We studied drug classes for which the first and second drugs were centrally registered in the European Union from 1995 to 2008. We assessed whether adverse drug reactions (ADRs) associated with one of the drugs also appeared in the Summary(More)
PURPOSE Subjects using functional foods with approved health claims may be more likely to be non-adherent with prescribed drug therapy. This study aimed to assess the influence of the use of phytosterol/-stanol-enriched functional foods on adherence to statin therapy among patients initiating treatment. METHODS We used data from the statin intervention(More)
OBJECTIVE To provide an evidence-based overview of drug treatment for long-term secondary prevention of myocardial infarction (MI). DATA SOURCES We conducted searches of MEDLINE (1966-August 2002), the Cochrane Controlled Trial Register, and the reference list of each identified study. STUDY SELECTION/DATA EXTRACTION Trials and meta-analyses were(More)
BACKGROUND Myocardial infarction (MI) is a common cause of death in developed countries. Long-term preventive pharmacotherapy has been shown to decrease mortality and morbidity after MI. Based on a literature search, studies of these therapies to date have estimated the use of monotherapy, whereas many patients are prescribed combination therapy. Thus,(More)
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