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mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.
SCFFBXO22 Regulates Histone H3 Lysine 9 and 36 Methylation Levels by Targeting Histone Demethylase KDM4A for Ubiquitin-Mediated Proteasomal Degradation
It is demonstrated that SCFFBXO22 regulates changes in histone H3 marks and cognate transcriptional control pathways by controlling KDM4A levels, and a potential role for FBXO 22 is suggested in development, differentiation, and disease through spatial and temporal control of KDM 4A activity.
Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer.
This study identifies EZH2 as a critical epigenetic regulator of ADT resistance and defines ASO-based cotargeting of EZh2 and AR as a promising strategy for the treatment of CRPC.
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy.
It is demonstrated that ARID1A aberrations resulted in limited chromatin accessibility to interferon (IFN) responsive genes, caused impaired IFN-gene expression, anemic T cell tumor infiltration, poor tumor immunity, and shortened host survival in many human cancer histologies as well as in murine cancer models.
3-(4-(Benzo[d]thiazol-2-yl)-1-phenyl-1H-pyrazol-3-yl) phenyl acetate induced Hep G2 cell apoptosis through a ROS-mediated pathway.
The Human Papillomavirus E6 Oncogene Represses a Cell Adhesion Pathway and Disrupts Focal Adhesion through Degradation of TAp63β upon Transformation
A major physiological role is identified for TAp63β in anchorage independent growth that might represent a new critical pathway in human carcinogenesis.
The G2/M Regulator Histone Demethylase PHF8 Is Targeted for Degradation by the Anaphase-Promoting Complex Containing CDC20
- H. Lim, Nevena Dimova, Mengyao Tan, Frederic D Sigoillot, R. King, Yang Shi
- BiologyMolecular and Cellular Biology
- 26 August 2013
It is shown that PHF8 protein levels are the highest during G2 phase and mitosis, and PHF7 protein stability is found to be regulated by the ubiquitin-proteasome system, and this findings suggest thatPHF8 is regulated by APCcdc20 and plays an important role in the G2/M transition.
Understanding Cullin-RING E3 Biology through Proteomics-based Substrate Identification*
Proteomic technologies for the identification of ubiquitin ligase targets are described, with a particular focus on members of the cullin-RING E3 class of ubiqu itin ligases, which use F-box proteins as substrate specific adaptor proteins.
Chromatin architecture transitions from zebrafish sperm through early embryogenesis.
This study reveals hinge-like domains in histone-packaged zebrafish sperm chromatin and determines that the initial formation of high-order chromatin architecture in zebra fish embryos occurs after ZGA primarily at enhancers bearing high H3K27ac.