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Transforming growth factor-β (TGF-β)-induced epithelial-mesenchymal transition (EMT) has been shown to be related to the pathogenesis of various diseases including lung cancer. Recently, microRNAs (miRNA) have been recognized as a new class of genes involved in human tumorigenesis. MiR-23a/24/27a is a miRNA cluster(More)
Cisplatin resistance is a major obstacle in the treatment of NSCLC, and its mechanism has not been fully elucidated. The objectives of the study were to determine the role of miR-378 in the sensitivity of lung adenocarcinoma cells to cisplatin (cDDP) and its working mechanism. With TargetScan and luciferase assay, miR-378 was found to directly target sCLU.(More)
—Case retrieval is the focal stage of Case-Based Reasoning systems whose quality is determined by the speed and accuracy of retrieva1. In this work, we aim at developing a better Case retrieval algorithm by using vector model and propose its new case retrieval Algorithm based on Structure Matrix, wich is derived to learn the kernel matrix for capturing the(More)
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