Mengran Guo

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The main purpose of this study was to develop and compare the pharmacokinetic behavior of two paliperidone palmitate (PP) nanosuspensions with different particle size after intramuscular (i.m.) administration. PP nanosuspensions were prepared by wet media milling method and the mean particle size of nanosuspension was controlled as 1,041 ± 6 nm (A) and 505(More)
Different formulation strategies have been proposed for poorly water-soluble drugs. The objective of this study is to give an in vitro and in vivo comparison of a solid dispersion, micronization, and nanocrystals, with lacidipine as a model substance. Micronized lacidipine was obtained by jet milling, and nanocrystals were prepared by bead milling. The d50(More)
Nanocrystal (NC) technology is an effective strategy to enhance the oral bioavailability for poorly water-soluble drugs. Stabilizers are essential and important in NC formulations due to its ability to decrease the system energy. Studies have revealed that stabilizers can affect the particle size and stability of the system. However, whether stabilizers can(More)
Lovastatin (LOV) is an antihyperlipidemic agent which exhibits low bioavailability due to its poor solubility. Therefore, a nanosuspension (NS) was developed as an efficient strategy to improve its oral bioavailability. To evaluate the pharmacokinetics of LOV-NS, a novel, sensitive, and rapid UPLC-MS/MS method was developed and validated for the(More)
Currently, nanosizing is becoming increasingly prevalent as an efficient way for the improvement of oral drug absorption. This study mainly focuses on two points, namely the crystal properties, and the in vitro and in vivo characterizations of drug crystals during the nanosizing process. We used glyburide, an oral type 2 diabetes (T2D) medication, as our(More)
The objective of this study was to compare the in vitro and in vivo performance of rod shaped and spherical like nanocrystals for oral administration. Lovastatin (LOV) was chosen as the model drug and LOV rod shaped nanocrystals (LOV-RNs) and spherical like nanocrystals (LOV-SNs) were prepared by sonoprecipitation and bead milling, respectively. The dry(More)
There is a strong desire to develop docetaxel (DTX) formulation with good therapeutic effectiveness in view of serious adverse reactions of the commercial formulation of DTX (Taxotere®). In this study, a redox-responsive DTX-vitamin E prodrug was successfully formulated into liposomes with the drug loading of 4.14% ± 0.10%. Compared with DTX liposomes, the(More)
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