Mengqing Zang

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BACKGROUND A tracheal matrix scaffold decellularized by detergent-enzymatic treatment has been shown as a promising scaffold in tracheal tissue engineering. The objectives of this study were to evaluate the impact of this technique on tracheal extracellular matrix integrity and characterize the matrix environment for recellularization. METHODS Brown(More)
The purpose of this study was to investigate the potential of silk fibroin and chitosan blend (SFCS) biological scaffolds for the purpose of cartilage tissue engineering with applications in tracheal tissue reconstruction. The capability of these scaffolds as cell carrier systems for chondrocytes was determined in vitro and cartilage generation in vivo on(More)
BACKGROUND The authors have previously demonstrated promising results with tissue engineered trachea in vitro using decellularized matrix scaffolds. The present study aims to investigate the applicability of the construct in vivo. METHODS Tracheae harvested from Brown Norway rats (donor) and Lewis rats (recipient) were decellularized with repeated(More)
The pedicled paraumbilical flap is a reliable tissue transfer for hand and forearm reconstruction. However, its size, pedicle length and/or thickness limit its application in resurfacing of extensive defects of the upper limb. To conquer those limitations, this flap was pre-expanded for 10-24 weeks prior to transfer in 25 patients and used as a pedicle flap(More)
Tracheal reconstruction remains a major clinical problem owing to the need for rigid support and a lining to maintain a patent lumen. The purpose of this study was to investigate the feasibility of microsurgical tracheal reconstruction in large animals. Two-stage tracheal reconstruction was attempted in six dogs and single-stage reconstruction in eight(More)
Elbow reconstruction is challenging for reconstructive surgeons. The purpose of this report is to present the results of the use of freestyle perforator-based propeller flap designed from the medial arm region for elbow reconstruction. The defects following soft tissue sarcoma resection at the medial and posterior elbow were repaired in two patients. The(More)
The anterolateral thigh flap has been used to reconstruct defects of lower trunk, perineum and upper thigh. We used a proximally based pedicled anterolateral thigh flap to repair an extensive gluteal defect ranging from the greater trochanter to the posterior midline and preserve the buttock contour. We conclude that the maximal lateral reach of the flap(More)
BACKGROUND Closure of donor-site defects from large cutaneous flap harvesting often faces significant morbidity, which limits the utility of workhorse flaps in large-soft-tissue defect reconstruction. To overcome this limitation, we introduced the concept of a second 'buddy' flap to reconstruct the donor-site defect. METHODS Between 2007 and 2010, the(More)