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The aim of the present study was to develop and provide evidence for the validity of a new measure of adolescent students' psychological need satisfaction at school, using a sample of Chinese students. We conducted four studies with four independent samples (total n = 1872). The first study aimed to develop items for the new instrument and to ascertain its(More)
A series of thienopyridinone derivatives was designed and synthesized as inhibitors of checkpoint kinase 1 (Chk1). Most of them exhibited moderate to good Chk1 inhibitory activities. Among them, compounds 8q, 8t, and 8w with excellent Chk1 inhibitory activities (IC50 values of 4.05, 6.23, and 2.33nM, respectively) displayed strong synergistic effects with(More)
Epithelial-to-mesenchymal transition (EMT) is essential for tumor invasion and metastasis. Snail has been proven to be a key regulator of EMT. Several studies have shown compelling evidence that Snail is also an important regulator of tumor growth and aggression; however, the role of Snail in the cell cycle has not been clarified. We decreased Snail(More)
A series of novel di- and tripeptidyl epoxyketone derivatives composed of β-amino acids were designed, synthesized and evaluated for their proteasome inhibitory activities and anti-proliferation activities against two multiple myeloma cell lines RPMI 8226 and NCI-H929 and normal cells (peripheral blood mononucleated cells). Among these tested compounds,(More)
An automatic control system composed of autofocus, recording and read-out process is designed for femtosecond laser micro-nanofabrication processing. By simulating three-dimensional intensity point spread function curve in the autofocus process, the interface between resin and glass has been found. Furthermore, information to be processed stored in form of(More)
Microdroplet dispensing has numerous applications in biotechnology, microelectronic packaging and microassembly. The rapid developments of these fields tend to demand smaller and smaller microdroplets. In order to achieve single picoliter-volume droplets, a piezoelectric micro-dispensing system is developed in this paper. The factors affecting the droplet(More)
BACKGROUND/AIMS Preeclampsia (PE) is a systemic inflammatory response syndrome involving varieties of cytokines, and previous studies have shown that IL-33 and its receptor IL-1RL1 play pivotal roles in the development of it. As a polygenetic hereditary disease, it is necessary to study the gene analysis for PE. Therefore, the present study was to determine(More)
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