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The Interaction of BDNF and NTRK2 Gene Increases the Susceptibility of Paranoid Schizophrenia
TLDR
The findings implied that single polymorphism of rs6265 rs1387923, rs2769605, and rs1565445 in BDNF and NTRK2 were not associated with the development of paranoid schizophrenia in a Han population, however, the interaction of BD NF and N TRK2 genes polymorphisms may be involved in the susceptibility to paranoid schizophrenia.
Guidelines Disconcordance in Acute Bipolar Depression: Data from the National Bipolar Mania Pathway Survey (BIPAS) in Mainland China
TLDR
The finding suggested the disconcordance with treatment guidelines in patients with an acute bipolar depression is common under naturalistic conditions in mainland China, and the predicting factors correlated with guidelines discon cordance include both psychiatrist-specific (clinicians from general hospitals) and patient-specific features.
Increased plasma leptin as a novel predictor for psychopathological depressive symptoms in chronic schizophrenia
TLDR
Plasma leptin levels were significantly higher in patients with schizophrenia than in healthy controls and a significant negative association between leptin levels and the depressed factor scores on the Positive and Negative Syndrome Scale (PANSS).
Macrophage migration inhibitory factor mediates metabolic dysfunction induced by atypical antipsychotic therapy
TLDR
It is suggested that MIF may be a tractable target for reducing the metabolic side effects of atypical antipsychotic therapy and uphold the potential pharmacogenomic value of MIF genotype determination.
The Interaction of TXNIP and AFq1 Genes Increases the Susceptibility of Schizophrenia
TLDR
The association between the interaction of TXNIP and AF1q with schizophrenia is found by using the MDR method followed by traditional statistical analysis and suggested statistically significant role of interaction ofTXNIP-rs2236566, TXNip-rs7211, and AF 1q-rs2769605 in schizophrenia susceptibility.
Pharmacotherapy for acute mania and disconcordance with treatment guidelines: bipolar mania pathway survey (BIPAS) in mainland China
TLDR
In mainland China, the disconcordance with treatment guidelines for a most recent acute manic or mixed episode was modest under naturalistic conditions, which suggests that special education based on treatment guidelines to practitioners in general hospitals is necessary in order to reduce the risk for disConcordant treatments.
Antipsychotics-associated obsessive-compulsive symptoms (OCS): individualized treatments and clinical benefits of memantine: a case report.
TLDR
This is the first case to report the benefit of memantine in SGAs-associated OCS, and suggests that memantine is a worth considering approach, especially when the OCS are resistant to routine managements.
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