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OBJECTIVE To investigate the in vitro and in vivo radiosensitization effect of an institutionally designed nanoliposome encapsulated cisplatin (NLE-CDDP). MATERIALS AND METHODS NLE-CDDP was developed by our institute. In vitro radiosensitization of NLE-CDDP was evaluated by colony forming assay in A549 cells. In vivo radiosensitization was studied with(More)
INTRODUCTION Lipid-coated cationic microbubbles represent a new class of agents with both diagnostic and therapeutic applications. The main goal of this study was to evaluate the efficiency of gene transfer through the combined use of microbubbles and ultrasound in rat carotid arteries. Furthermore, we assessed whether the cationic liposomal microbubbles(More)
Regulation of gene expression using small interfering RNA (siRNA) is a promising strategy for treatments of numerous diseases. However, the progress towards broad application of siRNA requires the development of safe and effective vectors that target to specific cells. In this study, we developed a novel recombinant high density lipoprotein (rHDL) vector(More)
BACKGROUND Natural high-density lipoproteins (HDL) possess important physiological functions to the transport of cholesterol from the peripheral tissues to the liver for metabolic degradation and excretion in the bile. METHODS AND RESULTS In this work, we took advantage of this pathway and prepared two different gadolinium (Gd)-DTPA-labeled(More)
The development of drug resistance in cancer cells is one of the major obstacles to achieving effective chemotherapy. We hypothesized that the combination of a doxorubicin (Dox) prodrug and microRNA (miR)21 inhibitor might show synergistic antitumor effects on drug-resistant breast cancer cells. In this study, we aimed to develop new high-density(More)
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