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Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline
TLDR
It is demonstrated that the primary piRNAs biogenesis pathway involves 3′→5′ processing of 31–37 nt intermediates and that Tdrkh promotes this final step of piRNA biogenesis but not the ping‐pong cycle, shed light on mechanisms underlying primary pi RNA biogenesis. Expand
Robust Covariance and Scatter Matrix Estimation under Huber's Contamination Model
Covariance matrix estimation is one of the most important problems in statistics. To accommodate the complexity of modern datasets, it is desired to have estimation procedures that not only canExpand
Sparse CCA via Precision Adjusted Iterative Thresholding
Sparse Canonical Correlation Analysis (CCA) has received considerable attention in high-dimensional data analysis to study the relationship between two sets of random variables. However, there hasExpand
VIPER: variability-preserving imputation for accurate gene expression recovery in single-cell RNA sequencing studies
TLDR
A key feature of the VIPER method is its ability to preserve gene expression variability across cells after imputation, which helps to facilitate accurate transcriptome quantification at the single-cell level. Expand
Robust Covariance Matrix Estimation via Matrix Depth
Covariance matrix estimation is one of the most important problems in statistics. To accommodate the complexity of modern datasets, it is desired to have estimation procedures that not only canExpand
Genomic analysis of oesophageal squamous-cell carcinoma identifies alcohol drinking-related mutation signature and genomic alterations
Approximately half of the world's 500,000 new oesophageal squamous-cell carcinoma (ESCC) cases each year occur in China. Here, we show whole-genome sequencing of DNA and RNA in 94 Chinese individualsExpand
Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma
TLDR
Both the mRNA and lincRNA signatures support a major role for protein kinase A (PKA) signaling in shaping the FLC gene expression landscape, and present novel candidate FLC oncogenes that merit further investigation. Expand
Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer
TLDR
DNA exome and RNA sequencing of matched primary tumors and multiple metastases from 16 patients found that genetic drivers were predominantly established in the primary tumor and maintained through metastatic spreading, suggesting that most metastatic drivers are established inThe primary tumor, despite the substantial heterogeneity seen in the metastases. Expand
Asymptotically Normal and Efficient Estimation of Covariate-Adjusted Gaussian Graphical Model
TLDR
The asymptotic normality result to perform support recovery through edge-wise adaptive thresholding is applied to identify gene–gene interactions using an eQTL dataset and achieves better interpretability and accuracy in comparison with a state-of-the-art method. Expand
Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection.
TLDR
Unique HBsAg-mutations in genotype-D, different than those described in genotypes B/C (rarely found in western countries), tightly correlate with OBI, and strongly affect HBs Ag-detection by altering HBV-antigenicity and/or viral-particle maturation, they may affect full-reliability of universal diagnostic-assays for HBs agestation. Expand
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