Menggui Huang

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Inhibitory neurons in the dorsal horn synthesize a variety of neurotransmitters, including GABA, glycine and a set of peptides. Here we show that three transcription factors, Ptf1a, Pax2, and Lbx1, which have been reported to promote a GABAergic cell fate, also specify glycinergic and peptidergic transmitter phenotypes. First, Ptf1a appears to be a master(More)
The involvement of microRNAs (miRNAs) in the development of the neural crest (NC) cells and other neuronal differentiation is still poorly understood. Here, we investigated the global function of miRNAs in embryonic development by examining the Wnt1-cre-mediated Dicer knockout mice. Dicer ablation resulted in malformation of the midbrain and cerebellum and(More)
Establishing the pattern of expression of transmitters and peptides as well as their receptors in different neuronal types is crucial for understanding the circuitry in various regions of the brain. Previous studies have demonstrated that the transmitter and peptide phenotypes in mouse dorsal spinal cord neurons are determined by the transcription factors(More)
Mutations in genes for presenilins (PS1 and PS2) lead to early-onset familial Alzheimer’s disease (FAD). It was recently shown that PS1 is required for macroautophagy in mouse blastocysts, and lysosomal proteolysis was proposed as a potential therapeutic target in FAD. Zhang et al. have meticulously tested that hypothesis and found it flawed. The previous(More)
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